Drug interactions and the evolution of antibiotic resistance

Pamela J. Yeh; Matthew J. Hegreness; Aviva Presser Aiden; Roy Kishony

doi:10.1038/nrmicro2133

Drug interactions and the evolution of antibiotic resistance

Pamela J. Yeh, Matthew J. Hegreness, Aviva Presser Aiden, Roy Kishony

Research output: Contribution to journal › Article › peer-review

294 Scopus citations

Abstract

Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.

Original language	English (US)
Pages (from-to)	460-466
Number of pages	7
Journal	Nature Reviews Microbiology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/nrmicro2133
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Microbiology
General Immunology and Microbiology
Infectious Diseases

Access to Document

10.1038/nrmicro2133

Cite this

@article{e2aa22e16e084f7fbc9f71c62aabc493,

title = "Drug interactions and the evolution of antibiotic resistance",

abstract = "Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.",

author = "Yeh, \{Pamela J.\} and Hegreness, \{Matthew J.\} and Aiden, \{Aviva Presser\} and Roy Kishony",

year = "2009",

doi = "10.1038/nrmicro2133",

language = "English (US)",

volume = "7",

pages = "460--466",

journal = "Nature Reviews Microbiology",

issn = "1740-1526",

publisher = "Nature Research",

number = "6",

}

TY - JOUR

T1 - Drug interactions and the evolution of antibiotic resistance

AU - Yeh, Pamela J.

AU - Hegreness, Matthew J.

AU - Aiden, Aviva Presser

AU - Kishony, Roy

PY - 2009

Y1 - 2009

N2 - Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.

AB - Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.

UR - https://www.scopus.com/pages/publications/65649124513

UR - https://www.scopus.com/inward/citedby.url?scp=65649124513&partnerID=8YFLogxK

U2 - 10.1038/nrmicro2133

DO - 10.1038/nrmicro2133

M3 - Article

C2 - 19444248

AN - SCOPUS:65649124513

SN - 1740-1526

VL - 7

SP - 460

EP - 466

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 6

ER -

Drug interactions and the evolution of antibiotic resistance

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this