Drug targets in infections with Ebola and Marburg viruses

Olinger G. Gene; Biggins E. Julia; Melanson R. Vanessa; Wahl Jensen Victoria; Geisbert W. Thomas; Hensley E. Lisa

doi:10.2174/187152609787847730

Drug targets in infections with Ebola and Marburg viruses

Olinger G. Gene, Biggins E. Julia, Melanson R. Vanessa, Wahl Jensen Victoria, Geisbert W. Thomas, Hensley E. Lisa

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

Original language	English (US)
Pages (from-to)	191-200
Number of pages	10
Journal	Infectious Disorders - Drug Targets
Volume	9
Issue number	2
DOIs	https://doi.org/10.2174/187152609787847730
State	Published - 2009
Externally published	Yes

Keywords

Drug targets
Ebola virus
Filoviridae
Immunotherapy
Marburg virus
Pathogenesis
Pathology
Therapeutics

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Microbiology (medical)

Access to Document

10.2174/187152609787847730

Cite this

@article{9cf13d382bb74f02abb5296c78f25186,

title = "Drug targets in infections with Ebola and Marburg viruses",

abstract = "The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.",

keywords = "Drug targets, Ebola virus, Filoviridae, Immunotherapy, Marburg virus, Pathogenesis, Pathology, Therapeutics",

author = "Gene, {Olinger G.} and Julia, {Biggins E.} and Vanessa, {Melanson R.} and Victoria, {Wahl Jensen} and Thomas, {Geisbert W.} and Lisa, {Hensley E.}",

year = "2009",

doi = "10.2174/187152609787847730",

language = "English (US)",

volume = "9",

pages = "191--200",

journal = "Infectious Disorders - Drug Targets",

issn = "1871-5265",

publisher = "Bentham Science Publishers B.V.",

number = "2",

}

TY - JOUR

T1 - Drug targets in infections with Ebola and Marburg viruses

AU - Gene, Olinger G.

AU - Julia, Biggins E.

AU - Vanessa, Melanson R.

AU - Victoria, Wahl Jensen

AU - Thomas, Geisbert W.

AU - Lisa, Hensley E.

PY - 2009

Y1 - 2009

N2 - The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

AB - The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

KW - Drug targets

KW - Ebola virus

KW - Filoviridae

KW - Immunotherapy

KW - Marburg virus

KW - Pathogenesis

KW - Pathology

KW - Therapeutics

UR - http://www.scopus.com/inward/record.url?scp=67649203671&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649203671&partnerID=8YFLogxK

U2 - 10.2174/187152609787847730

DO - 10.2174/187152609787847730

M3 - Review article

C2 - 19275706

AN - SCOPUS:67649203671

VL - 9

SP - 191

EP - 200

JO - Infectious Disorders - Drug Targets

JF - Infectious Disorders - Drug Targets

SN - 1871-5265

IS - 2

ER -

Drug targets in infections with Ebola and Marburg viruses

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this