Drug targets in infections with Ebola and Marburg viruses

Olinger G. Gene, Biggins E. Julia, Melanson R. Vanessa, Wahl Jensen Victoria, Geisbert W. Thomas, Hensley E. Lisa

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalInfectious Disorders - Drug Targets
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Drug targets
  • Ebola virus
  • Filoviridae
  • Immunotherapy
  • Marburg virus
  • Pathogenesis
  • Pathology
  • Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Microbiology (medical)

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  • Cite this

    Gene, O. G., Julia, B. E., Vanessa, M. R., Victoria, W. J., Thomas, G. W., & Lisa, H. E. (2009). Drug targets in infections with Ebola and Marburg viruses. Infectious Disorders - Drug Targets, 9(2), 191-200. https://doi.org/10.2174/187152609787847730