Drug targets in infections with Ebola and Marburg viruses

Olinger G. Gene; Biggins E. Julia; Melanson R. Vanessa; Wahl Jensen Victoria; Geisbert W. Thomas; Hensley E. Lisa

doi:10.2174/187152609787847730

Drug targets in infections with Ebola and Marburg viruses

Olinger G. Gene, Biggins E. Julia, Melanson R. Vanessa, Wahl Jensen Victoria, Geisbert W. Thomas, Hensley E. Lisa

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

Original language	English (US)
Pages (from-to)	191-200
Number of pages	10
Journal	Infectious Disorders - Drug Targets
Volume	9
Issue number	2
DOIs	https://doi.org/10.2174/187152609787847730
State	Published - 2009
Externally published	Yes

Keywords

Drug targets
Ebola virus
Filoviridae
Immunotherapy
Marburg virus
Pathogenesis
Pathology
Therapeutics

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Microbiology (medical)

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10.2174/187152609787847730

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title = "Drug targets in infections with Ebola and Marburg viruses",

abstract = "The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.",

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AU - Victoria, Wahl Jensen

AU - Thomas, Geisbert W.

AU - Lisa, Hensley E.

PY - 2009

Y1 - 2009

N2 - The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

AB - The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.

KW - Drug targets

KW - Ebola virus

KW - Filoviridae

KW - Immunotherapy

KW - Marburg virus

KW - Pathogenesis

KW - Pathology

KW - Therapeutics

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Drug targets in infections with Ebola and Marburg viruses

Abstract

Keywords

ASJC Scopus subject areas

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