D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex

Maïté Hotte, Sébastien Thuault, Fabienne Lachaise, Kelly Dineley, Hugh C. Hemmings, Angus C. Nairn, Thérèse M. Jay

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

We have recently shown a significant role of dopamine D1 receptors in recognition and temporal order memory retrieval for objects in rodents [Hotte M, Naudon L, Jay TM. Modulation of recognition and temporal order memory retrieval by dopamine D(1) receptor in rats. Neurobiol Learn Mem 2005;84:85-92]. The present study investigates the signal transduction pathways underlying dopamine D1 receptor modulation of retrieval performance in these memory tasks at different delays. We analyzed the level of phosphorylation of both CREB (cAMP response element binding protein) and DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa) in (1) the prefrontal cortex of rats that had performed the object recognition task, (2) the prefrontal and perirhinal cortices of rats that had performed the temporal order memory task for objects. For comparison, we explored the phosphorylation state of CREB and DARPP-32 in the prefrontal cortex, nucleus accumbens and hippocampus of rats having performed badly on the delayed spatial win-shift task after D1 blockade. The improvement in recognition and temporal order memory performance at a 4 h-delay was associated with an increased phosphorylation of both CREB and DARPP-32 in the prefrontal cortex of rats treated with the D1 agonist SKF 81297. By contrast, the significant impairment of delayed spatial memory retrieval after administration of the selective D1 antagonist SCH 23390 was associated with decreased phosphorylation of CREB and DARPP-32 in the prefrontal cortex. These results provide insight into molecular mechanisms involved in D1 receptor-dependent modulation of short- versus long-term memory in prefrontal cortex where DARPP-32 in synergy with CREB may represent a pivotal role.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalBehavioural Brain Research
Volume171
Issue number1
DOIs
StatePublished - Jul 15 2006
Externally publishedYes

Fingerprint

Dopamine and cAMP-Regulated Phosphoprotein 32
Cyclic AMP Response Element-Binding Protein
Prefrontal Cortex
Phosphorylation
Dopamine D1 Receptors
Repression (Psychology)
Long-Term Memory
Nucleus Accumbens
Rodentia
Signal Transduction
Hippocampus
Dopamine
Recognition (Psychology)

Keywords

  • CREB and DARPP-32
  • D receptors
  • Object recognition memory
  • PKA
  • Prefrontal cortex
  • Spatial working memory
  • Temporal order memory for objects

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. / Hotte, Maïté; Thuault, Sébastien; Lachaise, Fabienne; Dineley, Kelly; Hemmings, Hugh C.; Nairn, Angus C.; Jay, Thérèse M.

In: Behavioural Brain Research, Vol. 171, No. 1, 15.07.2006, p. 127-133.

Research output: Contribution to journalArticle

Hotte, Maïté ; Thuault, Sébastien ; Lachaise, Fabienne ; Dineley, Kelly ; Hemmings, Hugh C. ; Nairn, Angus C. ; Jay, Thérèse M. / D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. In: Behavioural Brain Research. 2006 ; Vol. 171, No. 1. pp. 127-133.
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