Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Meiling Lu, Yan Huang, Mark A. White, Xuri Wu, Nan Liu, Xiaodong Cheng, Yijun Chen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

Original languageEnglish (US)
Pages (from-to)11352-11354
Number of pages3
JournalChemical Communications
Volume48
Issue number92
DOIs
StatePublished - Oct 24 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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