Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Meiling Lu, Yan Huang, Mark White, Xuri Wu, Nan Liu, Xiaodong Cheng, Yijun Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product. This journal is

Original languageEnglish (US)
Pages (from-to)11352-11354
Number of pages3
JournalChemical Communications
Volume48
Issue number92
DOIs
StatePublished - Nov 28 2012

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Hydrides
Catalysis
Substrates

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase. / Lu, Meiling; Huang, Yan; White, Mark; Wu, Xuri; Liu, Nan; Cheng, Xiaodong; Chen, Yijun.

In: Chemical Communications, Vol. 48, No. 92, 28.11.2012, p. 11352-11354.

Research output: Contribution to journalArticle

Lu, M, Huang, Y, White, M, Wu, X, Liu, N, Cheng, X & Chen, Y 2012, 'Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase', Chemical Communications, vol. 48, no. 92, pp. 11352-11354. https://doi.org/10.1039/c2cc36334h
Lu, Meiling ; Huang, Yan ; White, Mark ; Wu, Xuri ; Liu, Nan ; Cheng, Xiaodong ; Chen, Yijun. / Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase. In: Chemical Communications. 2012 ; Vol. 48, No. 92. pp. 11352-11354.
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