Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Meiling Lu; Yan Huang; Mark A. White; Xuri Wu; Nan Liu; Xiaodong Cheng; Yijun Chen

doi:10.1039/c2cc36334h

Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Meiling Lu, Yan Huang, Mark A. White, Xuri Wu, Nan Liu, Xiaodong Cheng, Yijun Chen

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

Original language	English (US)
Pages (from-to)	11352-11354
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	92
DOIs	https://doi.org/10.1039/c2cc36334h
State	Published - Oct 24 2012

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.",

author = "Meiling Lu and Yan Huang and White, {Mark A.} and Xuri Wu and Nan Liu and Xiaodong Cheng and Yijun Chen",

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AU - Lu, Meiling

AU - Huang, Yan

AU - White, Mark A.

AU - Wu, Xuri

AU - Liu, Nan

AU - Cheng, Xiaodong

AU - Chen, Yijun

PY - 2012/10/24

Y1 - 2012/10/24

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AB - Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

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JO - Chemical Communications

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Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Abstract

ASJC Scopus subject areas

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