Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents

Keyphrases

• Aldehyde Inhibitor 25%
• Aldehydes 25%
• Amino Acid Side Chain 25%
• Carbonyl Group 25%
• Cathepsin L 50%
• Causative Agents 25%
• CoV-2 100%
• COVID-19 50%
• Cysteine Protease Inhibitor 25%
• Dual Inhibitor 100%
• Dual-acting Inhibitor 25%
• Dual-target Inhibitors 50%
• EC50 25%
• Glutamine 100%
• Heteroatom 25%
• Human Cathepsins 100%
• Human Cells 25%
• Hydrogen Bond (H-bond) 25%
• Hydrogen Bonding Interaction 25%
• Hydrophobic Amino Acids 25%
• Inactivating mutation 25%
• Indole 25%
• Inhibition Constant 25%
• Isostere 100%
• Leucine 25%
• Main Protease 25%
• Multi-target 50%
• New Inhibitors 25%
• Nirmatrelvir 25%
• Partial Preferences 25%
• Peptide Scaffold 25%
• Peptidomimetic Inhibitors 25%
• Peptidomimetics 50%
• Pfizer 25%
• Phenylalanine 25%
• Protease 75%
• Protein Maturation 25%
• Pyridinyl 50%
• Resistance Development 25%
• SARS-CoV-2 3CL Protease 100%
• Scaffold-based 25%
• Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) 25%
• Target-based Approach 25%
• Viral 25%
• Viral Infection 25%
• Viral Protease 50%
• Viral Proteins 25%
• X-ray Structure 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Alanine 42%
• Aldehyde 28%
• Amino Acid 28%
• Carbonyl Derivative 14%
• Cathepsin L 100%
• Cysteine Proteinase 14%
• EC50 14%
• Glutamine 100%
• Hydrogen 14%
• Hydrogen Bond 14%
• Indole 14%
• Infection 14%
• Leucine 14%
• Nirmatrelvir 14%
• Nitrogen 14%
• Peptide 14%
• Peptidomimetics 42%
• Phenylalanine 14%
• Proteinase 100%
• Proteinase Inhibitor 14%
• SARS Coronavirus 100%
• Viral Protein 14%
• Virus Infection 14%