Duration of topical steroid application after photorefractive keratectomy with mitomycin C

Mojgan Pakbin, Mehdi Khabazkhoob, Mohammad Pakravan, Akbar Fotouhi, Ebrahim Jafarzadehpour, Mohamadreza Aghamirsalim, Mohammad Amin Seyedian, Hassan Hashemi

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Contradictory results of postoperative steroid application in photorefractive keratectomy (PRK) led to a meta-analysis of the existing data to achieve a definite conclusion on the optimum dosage and duration of corticosteroid therapy after PRK. The overall pooled unstandardized mean difference (PUMD) of the corneal haze score was -0.20 (95% CI, -0.29 to -0.12). In subgroup analysis, the PUMD of the corneal haze score was statistically significant in 2 subgroups, -0.57 (-0.85 to -0.30) for 3 to 6 months postoperatively and -0.13 (-0.23 to -0.04) for ≤ 3 months postoperatively. Analysis of the PUMD of postoperative spherical equivalent in participants with low to moderate myopia (≥-6.00 D) and high myopia (<-6.00 D) showed positive effects of steroids on prevention of myopia regression. In conclusion, long-term topical steroid application after PRK seems unnecessary in low and moderate myopia. New randomized clinical trials using current technologies are recommended for postoperative treatments.

Original languageEnglish (US)
Pages (from-to)622-632
Number of pages11
JournalJournal of Cataract and Refractive Surgery
Issue number4
StatePublished - Apr 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems


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