Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis

Benedicte Saulier Le Dréan, Andrzej Nasiadka, Jianli Dong, Henry M. Krause

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Although many of the genes that pattern the segmented body plan of the Drosophila embryo are known, there remains much to learn in terms of how these genes and their products interact with one another. Like many of these gene products, the protein encoded by the pair-rule gene odd-skipped (Odd) is a DNA-binding transcription factor. Genetic experiments have suggested several candidate target genes for Odd, all of which appear to be negatively regulated. Here we use pulses of ectopic Odd expression to test the response of these and other segmentation genes. The results are complex, indicating that Odd is capable of repressing some genes wherever and whenever Odd is expressed, while the ability to repress others is temporally or spatially restricted. Moreover, one target gene fushi tarazu, is both repressed and activated by Odd, the outcome depending upon the stage of development. These results indicate that the activity of Odd is highly dependent upon the presence of cofactors and/or overriding inhibitors. Based on these results, and the segmental phenotypes generated by ectopic Odd, we suggest a number of new roles for Odd in the patterning of embryonic segments. These include gap-, pair-rule- and segment polarity-type functions.

Original languageEnglish (US)
Pages (from-to)4851-4861
Number of pages11
JournalDevelopment
Volume125
Issue number23
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Drosophila
  • Pair-rule
  • Segmentation
  • fushi tarazu
  • odd-skipped

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis'. Together they form a unique fingerprint.

  • Cite this

    Dréan, B. S. L., Nasiadka, A., Dong, J., & Krause, H. M. (1998). Dynamic changes in the functions of Odd-skipped during early Drosophila embryogenesis. Development, 125(23), 4851-4861.