Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice

N. Shimizu, S. Wood, K. Kushiro, S. Yanai, A. Perachio, Tomoko Makishima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The central vestibular system plays an important role in higher neural functions such as self-motion perception and spatial orientation. Its ability to store head angular velocity is called velocity storage mechanism (VSM), which has been thoroughly investigated across a wide range of species. However, little is known about the mouse VSM, because the mouse lacks typical ocular responses such as optokinetic after nystagmus or a dominant time constant of vestibulo-ocular reflex for which the VSM is critical. Experiments were conducted to examine the otolith-driven eye movements related to the VSM and verify its characteristics in mice. We used a novel approach to generate a similar rotating vector as a traditional off-vertical axis rotation (OVAR) but with a larger resultant gravito-inertial force (>1. g) by using counter rotation centrifugation. Similar to results previously described in other animals during OVAR, two components of eye movements were induced, i.e. a sinusoidal modulatory eye movement (modulation component) on which a unidirectional nystagmus (bias component) was superimposed. Each response is considered to derive from different mechanisms; modulations arise predominantly through linear vestibulo-ocular reflex, whereas for the bias, the VSM is responsible. Data indicate that the mouse also has a well-developed vestibular system through otoliths inputs, showing its highly conserved nature across mammalian species. On the other hand, to reach a plateau state of bias, a higher frequency rotation or a larger gravito-inertial force was considered to be necessary than other larger animals. Compared with modulation, the bias had a more variable profile, suggesting an inherent complexity of higher-order neural processes in the brain. Our data provide the basis for further study of the central vestibular system in mice, however, the underlying individual variability should be taken into consideration.

Original languageEnglish (US)
Pages (from-to)204-214
Number of pages11
JournalNeuroscience
Volume285
DOIs
StatePublished - Jan 9 2015

Fingerprint

Yaws
Otolithic Membrane
Eye Movements
Vestibulo-Ocular Reflex
Optokinetic Nystagmus
Pathologic Nystagmus
Motion Perception
Aptitude
Centrifugation
Head
Brain

Keywords

  • Eye movement
  • Off-vertical axis rotation (OVAR)
  • Otolith
  • Velocity storage mechanism
  • Vestibular

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice. / Shimizu, N.; Wood, S.; Kushiro, K.; Yanai, S.; Perachio, A.; Makishima, Tomoko.

In: Neuroscience, Vol. 285, 09.01.2015, p. 204-214.

Research output: Contribution to journalArticle

Shimizu, N. ; Wood, S. ; Kushiro, K. ; Yanai, S. ; Perachio, A. ; Makishima, Tomoko. / Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice. In: Neuroscience. 2015 ; Vol. 285. pp. 204-214.
@article{d454c994e1bb4dee9d9fa60fe0ca702d,
title = "Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice",
abstract = "The central vestibular system plays an important role in higher neural functions such as self-motion perception and spatial orientation. Its ability to store head angular velocity is called velocity storage mechanism (VSM), which has been thoroughly investigated across a wide range of species. However, little is known about the mouse VSM, because the mouse lacks typical ocular responses such as optokinetic after nystagmus or a dominant time constant of vestibulo-ocular reflex for which the VSM is critical. Experiments were conducted to examine the otolith-driven eye movements related to the VSM and verify its characteristics in mice. We used a novel approach to generate a similar rotating vector as a traditional off-vertical axis rotation (OVAR) but with a larger resultant gravito-inertial force (>1. g) by using counter rotation centrifugation. Similar to results previously described in other animals during OVAR, two components of eye movements were induced, i.e. a sinusoidal modulatory eye movement (modulation component) on which a unidirectional nystagmus (bias component) was superimposed. Each response is considered to derive from different mechanisms; modulations arise predominantly through linear vestibulo-ocular reflex, whereas for the bias, the VSM is responsible. Data indicate that the mouse also has a well-developed vestibular system through otoliths inputs, showing its highly conserved nature across mammalian species. On the other hand, to reach a plateau state of bias, a higher frequency rotation or a larger gravito-inertial force was considered to be necessary than other larger animals. Compared with modulation, the bias had a more variable profile, suggesting an inherent complexity of higher-order neural processes in the brain. Our data provide the basis for further study of the central vestibular system in mice, however, the underlying individual variability should be taken into consideration.",
keywords = "Eye movement, Off-vertical axis rotation (OVAR), Otolith, Velocity storage mechanism, Vestibular",
author = "N. Shimizu and S. Wood and K. Kushiro and S. Yanai and A. Perachio and Tomoko Makishima",
year = "2015",
month = "1",
day = "9",
doi = "10.1016/j.neuroscience.2014.11.022",
language = "English (US)",
volume = "285",
pages = "204--214",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Dynamic characteristics of otolith ocular response during counter rotation about dual yaw axes in mice

AU - Shimizu, N.

AU - Wood, S.

AU - Kushiro, K.

AU - Yanai, S.

AU - Perachio, A.

AU - Makishima, Tomoko

PY - 2015/1/9

Y1 - 2015/1/9

N2 - The central vestibular system plays an important role in higher neural functions such as self-motion perception and spatial orientation. Its ability to store head angular velocity is called velocity storage mechanism (VSM), which has been thoroughly investigated across a wide range of species. However, little is known about the mouse VSM, because the mouse lacks typical ocular responses such as optokinetic after nystagmus or a dominant time constant of vestibulo-ocular reflex for which the VSM is critical. Experiments were conducted to examine the otolith-driven eye movements related to the VSM and verify its characteristics in mice. We used a novel approach to generate a similar rotating vector as a traditional off-vertical axis rotation (OVAR) but with a larger resultant gravito-inertial force (>1. g) by using counter rotation centrifugation. Similar to results previously described in other animals during OVAR, two components of eye movements were induced, i.e. a sinusoidal modulatory eye movement (modulation component) on which a unidirectional nystagmus (bias component) was superimposed. Each response is considered to derive from different mechanisms; modulations arise predominantly through linear vestibulo-ocular reflex, whereas for the bias, the VSM is responsible. Data indicate that the mouse also has a well-developed vestibular system through otoliths inputs, showing its highly conserved nature across mammalian species. On the other hand, to reach a plateau state of bias, a higher frequency rotation or a larger gravito-inertial force was considered to be necessary than other larger animals. Compared with modulation, the bias had a more variable profile, suggesting an inherent complexity of higher-order neural processes in the brain. Our data provide the basis for further study of the central vestibular system in mice, however, the underlying individual variability should be taken into consideration.

AB - The central vestibular system plays an important role in higher neural functions such as self-motion perception and spatial orientation. Its ability to store head angular velocity is called velocity storage mechanism (VSM), which has been thoroughly investigated across a wide range of species. However, little is known about the mouse VSM, because the mouse lacks typical ocular responses such as optokinetic after nystagmus or a dominant time constant of vestibulo-ocular reflex for which the VSM is critical. Experiments were conducted to examine the otolith-driven eye movements related to the VSM and verify its characteristics in mice. We used a novel approach to generate a similar rotating vector as a traditional off-vertical axis rotation (OVAR) but with a larger resultant gravito-inertial force (>1. g) by using counter rotation centrifugation. Similar to results previously described in other animals during OVAR, two components of eye movements were induced, i.e. a sinusoidal modulatory eye movement (modulation component) on which a unidirectional nystagmus (bias component) was superimposed. Each response is considered to derive from different mechanisms; modulations arise predominantly through linear vestibulo-ocular reflex, whereas for the bias, the VSM is responsible. Data indicate that the mouse also has a well-developed vestibular system through otoliths inputs, showing its highly conserved nature across mammalian species. On the other hand, to reach a plateau state of bias, a higher frequency rotation or a larger gravito-inertial force was considered to be necessary than other larger animals. Compared with modulation, the bias had a more variable profile, suggesting an inherent complexity of higher-order neural processes in the brain. Our data provide the basis for further study of the central vestibular system in mice, however, the underlying individual variability should be taken into consideration.

KW - Eye movement

KW - Off-vertical axis rotation (OVAR)

KW - Otolith

KW - Velocity storage mechanism

KW - Vestibular

UR - http://www.scopus.com/inward/record.url?scp=84916613075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916613075&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2014.11.022

DO - 10.1016/j.neuroscience.2014.11.022

M3 - Article

C2 - 25446357

AN - SCOPUS:84916613075

VL - 285

SP - 204

EP - 214

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -