Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

Keyphrases

• G Protein-coupled Receptor 100%
• Chemokines 100%
• Receptor Activation 100%
• Chemokine Ligands 100%
• Glycine 100%
• Conformational Switching 100%
• Proline 100%
• Sigma-1 Receptor 50%
• Conformational Ensemble 50%
• N-loop 50%
• Receptor Function 25%
• Signaling Pathway 25%
• Leukocytes 25%
• Neutrophils 25%
• Specific mutation 25%
• Extracellular Loop 25%
• Terminal Residue 25%
• Receptor Subtypes 25%
• CXCL8 25%
• Chemokine CXCL8 25%
• Transmembrane 25%
• Loss Function 25%
• Molecular Dynamics Simulation 25%
• N-terminal Loop 25%
• Multiple Signaling Pathways 25%
• Receptor Activity 25%
• NMR Studies 25%
• Organogenesis 25%
• Diverse Functions 25%
• Receptor Selectivity 25%
• Indirect Interactions 25%
• Multidomain Structure 25%
• Ensemble Model 25%

Biochemistry, Genetics and Molecular Biology

• G Protein Coupled Receptor 100%
• Chemokine 100%
• Proline 80%
• N-Terminus 60%
• Signal Transduction 40%
• Conformational Ensembles 40%
• Leukocyte 20%
• Agonist 20%
• Interleukin 8 20%
• Receptor Affinity 20%
• Organogenesis 20%

Immunology and Microbiology

• Chemokine 100%
• Proline 80%
• Amino Terminal Sequence 60%
• Signal Transduction 40%
• Leukocyte 20%
• Agonist 20%
• Neutrophil 20%
• Receptor Affinity 20%
• Organogenesis 20%
• Interleukin 8 20%