Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis

Keyphrases

• Embryonic Stem Cells 100%
• 5-hydroxymethylcytosine (5hmC) 100%
• Stem Cell Population 100%
• High-content Analysis 100%
• DNA Hydroxymethylation 100%
• Dynamic Heterogeneity 100%
• SOX17 25%
• FOXA2 25%
• Cell Population 16%
• Colocalization 16%
• Octamer-binding Transcription Factor 4 (OCT4) 16%
• Population-based 8%
• Transcription Factor 8%
• Epigenetics 8%
• Cell Surface Markers 8%
• DNA Modification 8%
• 4-fold 8%
• Nuclear DNA (nDNA) 8%
• Cytosine 8%
• Methylation Status 8%
• Mouse Embryonic Stem Cells (mESCs) 8%
• Mutually Exclusive 8%
• Stem Cell Therapy 8%
• Temporal Profile 8%
• Epigenetic Marks 8%
• Tight 8%
• Stem Cell Fate 8%
• Four-level 8%
• Global DNA Methylation 8%
• Therapeutic Safety 8%
• Heterochromatic Regions 8%
• Pluripotency 8%
• Regenerative Potential 8%
• Stem Cell Culture 8%
• Heterogeneous Spectrum 8%
• Chromatin Domains 8%
• Single-cell Screening 8%
• Pluripotency Markers 8%
• Differential Markers 8%
• Nuclear Patterns 8%
• Co-distribution 8%
• Endodermal Cell 8%
• Hydroxymethylation 8%
• Exclusive Territories 8%
• Lineage-specific Differentiation 8%
• Endodermal Differentiation 8%
• Optical Nanoscopy 8%
• Super-resolution Imaging 8%

Biochemistry, Genetics and Molecular Biology

• DNA Methylation 100%
• Embryonic Stem Cell 100%
• Content Analysis 100%
• Epigenetics 66%
• Transcription Factors 33%
• Cell Surface Marker 33%
• Stem Cell 33%
• Optics 33%
• Nuclear DNA 33%
• 5-Hydroxymethylcytosine 33%
• DNA Modification 33%
• Cell Fate 33%
• Cell Screening 33%
• Stem Cell Culture 33%
• Cytosine 33%
• 5-Methylcytosine 33%