Dynamic phase transitions in cell spreading

Hans Günther Döbereiner, Benjamin Dubin-Thaler, Grégory Giannone, Harry S. Xenias, Michael Sheetz

Research output: Contribution to journalArticle

101 Scopus citations


The isotropic spreading of mouse embryonic fibroblasts on fibronectin-coated substrates was monitored. The power-law area growth with distinct exponents in three sequential phases, that includes basal, continuous and contractile spreading were found. It was also observed that to characterize local membrane dynamics at the spreading front, high resolution differential interference contrast microscopy was used. The results show that the classification of cell spreading into phases with distinct functional characteristics and protein activity was used as a paradigm for a general program of a phase classification of cellular phenotype.

Original languageEnglish (US)
JournalPhysical Review Letters
Issue number10
StatePublished - Sep 3 2004
Externally publishedYes


ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Döbereiner, H. G., Dubin-Thaler, B., Giannone, G., Xenias, H. S., & Sheetz, M. (2004). Dynamic phase transitions in cell spreading. Physical Review Letters, 93(10). https://doi.org/10.1103/PhysRevLett.93.108105