Dynamic phase transitions in cell spreading

Hans Günther Döbereiner, Benjamin Dubin-Thaler, Grégory Giannone, Harry S. Xenias, Michael Sheetz

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

The isotropic spreading of mouse embryonic fibroblasts on fibronectin-coated substrates was monitored. The power-law area growth with distinct exponents in three sequential phases, that includes basal, continuous and contractile spreading were found. It was also observed that to characterize local membrane dynamics at the spreading front, high resolution differential interference contrast microscopy was used. The results show that the classification of cell spreading into phases with distinct functional characteristics and protein activity was used as a paradigm for a general program of a phase classification of cellular phenotype.

Original languageEnglish (US)
JournalPhysical Review Letters
Volume93
Issue number10
DOIs
StatePublished - Sep 3 2004
Externally publishedYes

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cells
phenotype
fibroblasts
mice
exponents
membranes
microscopy
proteins
interference
high resolution

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Döbereiner, H. G., Dubin-Thaler, B., Giannone, G., Xenias, H. S., & Sheetz, M. (2004). Dynamic phase transitions in cell spreading. Physical Review Letters, 93(10). https://doi.org/10.1103/PhysRevLett.93.108105

Dynamic phase transitions in cell spreading. / Döbereiner, Hans Günther; Dubin-Thaler, Benjamin; Giannone, Grégory; Xenias, Harry S.; Sheetz, Michael.

In: Physical Review Letters, Vol. 93, No. 10, 03.09.2004.

Research output: Contribution to journalArticle

Döbereiner, HG, Dubin-Thaler, B, Giannone, G, Xenias, HS & Sheetz, M 2004, 'Dynamic phase transitions in cell spreading', Physical Review Letters, vol. 93, no. 10. https://doi.org/10.1103/PhysRevLett.93.108105
Döbereiner, Hans Günther ; Dubin-Thaler, Benjamin ; Giannone, Grégory ; Xenias, Harry S. ; Sheetz, Michael. / Dynamic phase transitions in cell spreading. In: Physical Review Letters. 2004 ; Vol. 93, No. 10.
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