Dynamic phase transitions in cell spreading

Hans Günther Döbereiner, Benjamin Dubin-Thaler, Grégory Giannone, Harry S. Xenias, Michael P. Sheetz

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

The isotropic spreading of mouse embryonic fibroblasts on fibronectin-coated substrates was monitored. The power-law area growth with distinct exponents in three sequential phases, that includes basal, continuous and contractile spreading were found. It was also observed that to characterize local membrane dynamics at the spreading front, high resolution differential interference contrast microscopy was used. The results show that the classification of cell spreading into phases with distinct functional characteristics and protein activity was used as a paradigm for a general program of a phase classification of cellular phenotype.

Original languageEnglish (US)
Article number108105
Pages (from-to)108105-1-108105-4
JournalPhysical Review Letters
Volume93
Issue number10
DOIs
StatePublished - Sep 3 2004
Externally publishedYes

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Döbereiner, H. G., Dubin-Thaler, B., Giannone, G., Xenias, H. S., & Sheetz, M. P. (2004). Dynamic phase transitions in cell spreading. Physical Review Letters, 93(10), 108105-1-108105-4. [108105]. https://doi.org/10.1103/PhysRevLett.93.108105