Dynamics of arterial pressure components in a sheep model of hemorrhage

Christopher G. Scully, George Kramer, David G. Strauss

Research output: Chapter in Book/Report/Conference proceedingConference contribution


There is a need for accurate monitors that can track blood loss and report a patient's current physiological response. We explored phase coherence between components of the arterial blood pressure waveform for this purpose. Adult conscious sheep underwent 25 mL/kg<inf>body-Weight</inf>, hemorrhages over 15 minutes (14 total hemorrhage experiments) while continuous arterial blood pressure measurements were made. Phase coherence from a single arterial pressure monitor was assessed between all combinations of the pulse-pulse interval, systolic blood pressure, and pulse pressure sequences as a measure of the synchronization between the component dynamics. Phase coherence measures were compared during baseline, the peak compensatory response and a decompensation phase. Phase coherence in the range of 0.06-0. 15 Hz between the pulse-pulse interval and systolic blood pressure sequences as well as the systolic blood pressure and pulse pressure sequences was elevated during the peak compensation period. Analytical techniques to assess the relationship between signals recorded during hemorrhage can be explored for their potential predictive capabilities.

Original languageEnglish (US)
Title of host publicationComputing in Cardiology
PublisherIEEE Computer Society
Number of pages4
StatePublished - 2014
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: Sep 7 2014Sep 10 2014


Other41st Computing in Cardiology Conference, CinC 2014
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • General Computer Science


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