Dynamics of arterial pressure components in a sheep model of hemorrhage

Christopher G. Scully, George C. Kramer, David G. Strauss

Research output: Contribution to journalConference articlepeer-review


There is a need for accurate monitors that can track blood loss and report a patient's current physiological response. We explored phase coherence between components of the arterial blood pressure waveform for this purpose. Adult conscious sheep underwent 25 mL/kgbody-Weight, hemorrhages over 15 minutes (14 total hemorrhage experiments) while continuous arterial blood pressure measurements were made. Phase coherence from a single arterial pressure monitor was assessed between all combinations of the pulse-pulse interval, systolic blood pressure, and pulse pressure sequences as a measure of the synchronization between the component dynamics. Phase coherence measures were compared during baseline, the peak compensatory response and a decompensation phase. Phase coherence in the range of 0.06-0. 15 Hz between the pulse-pulse interval and systolic blood pressure sequences as well as the systolic blood pressure and pulse pressure sequences was elevated during the peak compensation period. Analytical techniques to assess the relationship between signals recorded during hemorrhage can be explored for their potential predictive capabilities.

Original languageEnglish (US)
Article number7043040
Pages (from-to)305-308
Number of pages4
JournalComputing in Cardiology
Issue numberJanuary
StatePublished - 2014
Externally publishedYes
Event41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States
Duration: Sep 7 2014Sep 10 2014

ASJC Scopus subject areas

  • General Computer Science
  • Cardiology and Cardiovascular Medicine


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