Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression

Seema H. Bajaria, Glenn Webb, Miles Cloyd, Denise Kirschner

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Understanding the dynamics of naive and memory CD4+ T cells in the immune response to HIV-1 infection can help elucidate typical disease progression patterns observed in HIV-1 patients. Although infection markers such as CD4+ T-cell count and viral load are monitored in patient blood, the lymphatic tissues (LT) have been shown to be an important viral reservoir. Here, we introduce the first comprehensive theoretical model of disease progression based on T-cell subsets and virus circulating between the two compartments of LT and blood. We use this model to predict several trademarks observed in adult HIV-1 disease progression such as the establishment of a setpoint in the asymptomatic stage. Our model predicts that both host and viral elements play a role in determining different disease progression patterns. Viral factors include viral infectivity and production rates, whereas host factors include elements of specific immunity. We also predict the effect of highly active antiretroviral therapy and treatment cessation on cellular and viral dynamics in both blood and LT.

Original languageEnglish (US)
Pages (from-to)41-58
Number of pages18
JournalJournal of Acquired Immune Deficiency Syndromes
Volume30
Issue number1
DOIs
StatePublished - May 1 2002

Fingerprint

Disease Progression
HIV-1
Lymphoid Tissue
T-Lymphocytes
Withholding Treatment
Patents
Highly Active Antiretroviral Therapy
T-Lymphocyte Subsets
CD4 Lymphocyte Count
Viral Load
HIV Infections
Immunity
Theoretical Models
Viruses
Infection

Keywords

  • HAART
  • HIV-1
  • Homing
  • Mathematical model
  • Memory
  • Naive

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression. / Bajaria, Seema H.; Webb, Glenn; Cloyd, Miles; Kirschner, Denise.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 30, No. 1, 01.05.2002, p. 41-58.

Research output: Contribution to journalArticle

Bajaria, Seema H. ; Webb, Glenn ; Cloyd, Miles ; Kirschner, Denise. / Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression. In: Journal of Acquired Immune Deficiency Syndromes. 2002 ; Vol. 30, No. 1. pp. 41-58.
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