TY - JOUR
T1 - Dynasore puts a new spin on dynamin
T2 - a surprising dual role during vesicle formation
AU - Nankoe, Sharif R.
AU - Sever, Sanja
PY - 2006/12
Y1 - 2006/12
N2 - During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
AB - During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
UR - http://www.scopus.com/inward/record.url?scp=33751337381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751337381&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2006.10.004
DO - 10.1016/j.tcb.2006.10.004
M3 - Short survey
C2 - 17064900
AN - SCOPUS:33751337381
SN - 0962-8924
VL - 16
SP - 607
EP - 609
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 12
ER -