Dynorphin A(1-8) immunoreactive cell bodies, dendrites and terminals are postsynaptic to calcitonin gene-related peptide primary afferent terminals in the monkey dorsal horn

Susan M. Carlton, Elizabeth S. Hayes

    Research output: Contribution to journalArticle

    26 Scopus citations

    Abstract

    In the present study, Dynorphin A(1-8) (DYN)-immunoreactive cell bodies, dendrites and terminals are observed postsynaptic to calcitonin gene-related peptide (CGRP)-immunoreactive terminals in laminae I and II. With the demonstration of axosomatic, axodendritic as well as axoaxonic interactions, we hypothesize that CGRP-containing primary afferent terminals can effect processing at the level of the cell body (possibly influencing the manufacture of DYN and/or the firing rate of DYN-containing cells) and also modulate the output of DYN terminals in laminae I and II of the monkey dorsal horn. These structural relationships may play an important role in the processing of noxious input at the spinal cord level.

    Original languageEnglish (US)
    Pages (from-to)124-128
    Number of pages5
    JournalBrain Research
    Volume504
    Issue number1
    DOIs
    StatePublished - Dec 11 1989

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    Keywords

    • Calcitonin gene-related peptide
    • Dynorphin A
    • Immunogold
    • Immunohistochemistry
    • Pain
    • Primary afferent
    • Primate
    • Spinal cord

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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