Dysfunctional Immunometabolism in HIV Infection: Contributing Factors and Implications for Age-Related Comorbid Diseases

Tiffany R. Butterfield, Alan L. Landay, Joshua J. Anzinger

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Purpose of Review: An increasing body of evidence indicates that persons living with HIV (PLWH) display dysfunctional immunometabolism. Here, we provide an updated review of this topic and its relationship to HIV-associated immune stimuli and age-related disease. Recent Findings: HIV infection alters immunometabolism by increasing reliance on aerobic glycolysis for energy and productive infection and repurposing oxidative phosphorylation machinery for immune cell proliferation and survival. Recent studies in PLWH with diabetes mellitus or cardiovascular disease have identified an association with elevated T cell and monocyte glucose metabolism, respectively. Immunometabolic dysfunction has also been observed in PLWH in frailty and additional studies suggest a role for immunometabolism in non-AIDS defining cancers and neurocognitive disease. There is a plethora of HIV-associated immune stimuli that could drive immunometabolic dysfunction and age-related disease in PLWH, but studies directly examining their relationship are lacking. Summary: Immunometabolic dysfunction is characteristic of HIV infection and is a potential link between HIV-associated stimuli and age-related comorbidities.

Original languageEnglish (US)
Pages (from-to)125-137
Number of pages13
JournalCurrent HIV/AIDS Reports
Issue number2
StatePublished - Apr 1 2020
Externally publishedYes


  • Antiretroviral therapy
  • Glycolysis
  • HIV
  • Immune activation
  • Immunometabolism
  • Oxidative phosphorylation

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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