Early Biomarkers of Acute and Chronic Pancreatitis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Advanced stages of chronic pancreatitis and pancreatic cancers (PCs) are very serious diseases with very poor prognosis. Therefore, identification of reliable and specific biomarker(s) at early stages of the diseases could be key to their early prevention and therapy. In this chapter, currently used and putative biomarkers of acute and chronic pancreatitis and PC are summarized. Total serum lipase and/or amylase are most widely used biomarkers of acute pancreatitis; lipase assay being more sensitive and specific than that of amylase. Imaging technologies provide key support for the diagnosis of both acute and chronic pancreatitis. Biomarkers of chronic pancreatitis are poorly developed and remain challenging because of impaired secretory components of exocrine pancreas. The focus of future clinical diagnosis of chronic pancreatitis and PC lies in identification of biomarkers using omics and microRNA arrays along with imaging technologies in well-defined experimental models and their validation in patients diagnosed with various stages of chronic pancreatitis and PC.

Original languageEnglish (US)
Title of host publicationBiomarkers in Toxicology
PublisherElsevier
Pages341-353
Number of pages13
ISBN (Electronic)9780128146552
ISBN (Print)9780128146569
DOIs
StatePublished - Jan 1 2019

Keywords

  • Acute pancreatitis
  • Chronic pancreatitis
  • Diagnostic biomarkers
  • Functional biomarkers
  • Pancreatic cancer

ASJC Scopus subject areas

  • Medicine(all)

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