Early Clinical Experience with Delafloxacin: A Case Series

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Background: The most recently approved fluoroquinolone for use in the US and Europe, delafloxacin (DLX) provides broad-spectrum coverage, improved side effect profile, and excellent potency. Currently approved for the treatment of acute bacterial skin infections and community-acquired pneumonia, DLX may be useful in the treatment of other infections given the longstanding versatility of other fluoroquinolones. Materials and Methods: This is a retrospective review of adult patients treated with DLX at The University of Texas Medical Branch, Galveston, TX from January 1, 2018 to February 1, 2020 using pre-existing electronic medical records. Simple statistics were calculated using Microsoft Excel. Results: Five patients were prescribed DLX (median age 59 years, 40% female, 100% outpatient) with a median treatment duration of seven days. Prescriptions were initiated by infectious diseases specialists (2/5, 40%), emergency medicine physicians (2/5, 40%), and ophthalmologists (1/5, 20%). The most common conditions treated were prosthetic joint infections (PJI) and acute skin and soft tissue infections (each n = 2). Both PJIs were caused by multi-drug-resistant Staphylococcus epidermidis. Off-label utilization was high (3/5, 60%). No patient experienced any documented treatment failure due to delafloxacin and there were zero reported adverse events. Conclusions: A new antibiotic with valuable characteristics, DLX treatment was highly successful in this case series, including with multiple off-label indications. Real-world clinical data with delafloxacin are currently scant. Prospective data would be useful for identifying future clinical niches for this new fluoroquinolone.

Original languageEnglish (US)
Pages (from-to)359-363
Number of pages5
JournalAmerican Journal of the Medical Sciences
Issue number4
StatePublished - Apr 2022


  • Antimicrobial therapy
  • Clinical infectious diseases
  • Delafloxacin
  • Fluoroquinolones

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Early Clinical Experience with Delafloxacin: A Case Series'. Together they form a unique fingerprint.

Cite this