Early diagnosis of rickettsioses by electrochemiluminscence

Gary Wen, Jere W. McBride, Xiaofeng Zhang, Juan P. Olano

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The diagnosis of acute rickettsioses during the acute phase of the disease is challenging. We present preliminary evidence that antigen-capture using streptavidin-coated magnetic beads with biotinylated smti-rickettsia typhi rabbit polyclonal antibodies followed by electrochemiluminescent detection with ruthenylated antibodies of the same specificity could be used for the diagnosis of rickettsial diseases in the acute phase.

Original languageEnglish (US)
Title of host publicationCentury of Rickettsiology; Emerging, Reemerging Rickettsioses, Molecular Diagnostics. amd Emerging Veterinary Rickettsioses
PublisherBlackwell Publishing Inc.
Number of pages5
ISBN (Print)1573316393, 9781573316392
StatePublished - Oct 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Electrochemiluminescence
  • Rickettsia typhi
  • Rickettsioses
  • Ruthenium (II) tris-bipyridine
  • Tripropylamine

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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