Early findings of prospective anti-HLA donor specific antibodies monitoring study in pancreas transplantation

Indiana University Health Experience

Muhammad Mujtaba, Jonathan A. Fridell, Nancy Higgins, Asif A. Sharfuddin, Muhammad S. Yaqub, Praveen Kandula, Jeanne Chen, Dennis P. Mishler, Andrew Lobashevsky, Benita Book, John Powelson, Tim E. Taber

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The significance of donor-specific antibodies (DSA) is not well known in the setting of pancreas transplantation. Since December 2009, we prospectively followed pancreas transplant patients with single-antigen-luminex-bead testing at one, two, three, six, and then every six months for the first two yr. Thirty-five of the 92 patients that underwent pancreas transplantation (13 pancreas-alone [PTA], 20 with a kidney [SPK], and two after a kidney [PAK]) agreed to participate in study. Median age at transplant was 45 yr and follow-up was 23 months. Majority were Caucasian (n = 33) and male (n = 18). Rabbit anti-thymocyte globulin induction was used. Median HLA-mismatch was 4.2 ± 1.1. Eight patients (7SPK, 1PAK) developed post-transplant DSA at median follow-up of 76 d (26-119), 1 SPK had pre-formed DSA. Seven patients had both class I and class II DSA, one with class I and one with class II only. Mean peak class I DSA-MFI was 3529 (±1456); class II DSA-MFI was 5734 (±3204) whereas cumulative DSA MFI (CI + CII) was 9264 (±4233). No difference was observed in the patient and donor demographics among patients with and without DSA. One patient in non-DSA group developed acute cellular rejection of pancreas. From our data it appears that post-transplant DSA in pancreas allograft recipients may not impact the early-pancreatic allograft outcomes. The utility of prospective DSA monitoring in pancreatic transplant patients needs further evaluation and long-term follow-up.

Original languageEnglish (US)
JournalClinical Transplantation
Volume26
Issue number5
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Pancreas Transplantation
Tissue Donors
Antibodies
Health
Pancreas
Transplants
Allografts
Kidney
Antilymphocyte Serum
Demography

Keywords

  • Antibody mediated rejection
  • Donor-specific antibodies
  • Pancreas survival
  • Pancreas transplant

ASJC Scopus subject areas

  • Transplantation

Cite this

Early findings of prospective anti-HLA donor specific antibodies monitoring study in pancreas transplantation : Indiana University Health Experience. / Mujtaba, Muhammad; Fridell, Jonathan A.; Higgins, Nancy; Sharfuddin, Asif A.; Yaqub, Muhammad S.; Kandula, Praveen; Chen, Jeanne; Mishler, Dennis P.; Lobashevsky, Andrew; Book, Benita; Powelson, John; Taber, Tim E.

In: Clinical Transplantation, Vol. 26, No. 5, 09.2012.

Research output: Contribution to journalArticle

Mujtaba, M, Fridell, JA, Higgins, N, Sharfuddin, AA, Yaqub, MS, Kandula, P, Chen, J, Mishler, DP, Lobashevsky, A, Book, B, Powelson, J & Taber, TE 2012, 'Early findings of prospective anti-HLA donor specific antibodies monitoring study in pancreas transplantation: Indiana University Health Experience', Clinical Transplantation, vol. 26, no. 5. https://doi.org/10.1111/ctr.12005
Mujtaba, Muhammad ; Fridell, Jonathan A. ; Higgins, Nancy ; Sharfuddin, Asif A. ; Yaqub, Muhammad S. ; Kandula, Praveen ; Chen, Jeanne ; Mishler, Dennis P. ; Lobashevsky, Andrew ; Book, Benita ; Powelson, John ; Taber, Tim E. / Early findings of prospective anti-HLA donor specific antibodies monitoring study in pancreas transplantation : Indiana University Health Experience. In: Clinical Transplantation. 2012 ; Vol. 26, No. 5.
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