Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon

Melanie D. Bird, Chin Fun Chu, Alison J. Johnson, Gregg Milligan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required T-cell-produced gamma interferon (IFN-γ). Transfer of activated CD8+ T cells to irradiated C57BL/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the IFN-γ receptor (IFN-γR). Early virus clearance was demonstrated in radiation chimeras in which IFN-γR expression was limited to parenchymal cells, but resolution was significantly delayed in chimeras deficient in IFN-γR expression and chimeras expressing IFN-γR only on hematopoietic cells. Together, these results suggest that early IFN-γ-mediated protection was manifested mainly by stimulation of genital parenchymal cells.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalJournal of Virology
Volume81
Issue number1
DOIs
StatePublished - Jan 2007

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Human herpesvirus 2
Human Herpesvirus 2
Virus Diseases
interferon-gamma
genitalia
Interferon-gamma
chimerism
receptors
mice
Radiation Chimera
infection
Viruses
T-Lymphocytes
Thymidine Kinase
T-lymphocytes
cells
thymidine kinase
Inbred C57BL Mouse
viruses
female genitalia

ASJC Scopus subject areas

  • Immunology

Cite this

Early resolution of herpes simplex virus type 2 infection of the murine genital tract involves stimulation of genital parenchymal cells by gamma interferon. / Bird, Melanie D.; Chu, Chin Fun; Johnson, Alison J.; Milligan, Gregg.

In: Journal of Virology, Vol. 81, No. 1, 01.2007, p. 423-426.

Research output: Contribution to journalArticle

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