Eastern equine encephalitis virus infection

Electron microscopic studies of mouse central nervous system

Frederick A. Murphy, Sylvia G. Whitfield

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Eastern equine encephalitis (EEE) virus infection of the central nervous system of newborn mice was examined by light and electron microscopy. Initial changes in brain architecture were due to interstitial and perivascular edema formation; the resulting extracellular space increased throughout the course of infection. Neuronal damage consisted of disruption of cytoplasmic organization and terminated in crenation, vacuolation, and membrane breakdown. Virus nucleoids (28 nm in diameter) were formed in the cytoplasmic matrix of all types of brain cells except endothelium, and viral maturation took place via nucleoid budding primarily through plasma membranes. Virus particles were 55 nm in diameter and were similar in morphology to other group A arboviruses.

Original languageEnglish (US)
Pages (from-to)131-146
Number of pages16
JournalExperimental and Molecular Pathology
Volume13
Issue number2
DOIs
StatePublished - 1970

Fingerprint

Eastern equine encephalitis virus
Neurology
Virus Diseases
Viruses
Central Nervous System
Electrons
Alphavirus
Brain
Extracellular Space
Virion
Endothelium
Edema
Electron Microscopy
Cell Membrane
Cell membranes
Light
Electron microscopy
Optical microscopy
Membranes
Infection

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Eastern equine encephalitis virus infection : Electron microscopic studies of mouse central nervous system. / Murphy, Frederick A.; Whitfield, Sylvia G.

In: Experimental and Molecular Pathology, Vol. 13, No. 2, 1970, p. 131-146.

Research output: Contribution to journalArticle

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