Eastern equine encephalitis virus infection: Electron microscopic studies of mouse central nervous system

Frederick A. Murphy, Sylvia G. Whitfield

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Eastern equine encephalitis (EEE) virus infection of the central nervous system of newborn mice was examined by light and electron microscopy. Initial changes in brain architecture were due to interstitial and perivascular edema formation; the resulting extracellular space increased throughout the course of infection. Neuronal damage consisted of disruption of cytoplasmic organization and terminated in crenation, vacuolation, and membrane breakdown. Virus nucleoids (28 nm in diameter) were formed in the cytoplasmic matrix of all types of brain cells except endothelium, and viral maturation took place via nucleoid budding primarily through plasma membranes. Virus particles were 55 nm in diameter and were similar in morphology to other group A arboviruses.

Original languageEnglish (US)
Pages (from-to)131-146
Number of pages16
JournalExperimental and Molecular Pathology
Volume13
Issue number2
DOIs
StatePublished - Oct 1970

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Eastern equine encephalitis virus infection: Electron microscopic studies of mouse central nervous system'. Together they form a unique fingerprint.

  • Cite this