Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

Ferenc Torma, Zoltan Bori, Erika Koltai, Klara Felszeghy, Gabriella Vacz, Lauren Koch, Steven Britton, Istvan Boldogh, Zsolt Radak

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Exercise capacity and dietary restriction (DR) are linked to improved quality of life, including enhanced brain function and neuro-protection. Brain derived neurotrophic factor (BDNF) is one of the key proteins involved in the beneficial effects of exercise on brain. Low capacity runner (LCR) and high capacity runner (HCR) rats were subjected to DR in order to investigate the regulation of BDNF. HCR-DR rats out-performed other groups in a passive avoidance test. BDNF content increased significantly in the hippocampus of HCR-DR groups compared to control groups (p<. 0.05). The acetylation of H3 increased significantly only in the LCR-DR group. However, chip-assay revealed that the specific binding between acetylated histone H3 and BNDF promoter was increased in both LCR-DR and HCR-DR groups. In spite of these increases in binding, at the transcriptional level only, the LCR-DR group showed an increase in BDNF mRNA content. Additionally, DR also induced the activity of cAMP response element-binding protein (CREB), while the content of SIRT1 was not altered. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) was elevated in HCR-DR groups. But, based on the levels of nuclear respiratory factor-1 and cytocrome c oxidase, it appears that DR did not cause mitochondrial biogenesis. The data suggest that DR-mediated induction of BDNF levels includes chromatin remodeling. Moreover, DR does not induce mitochondrial biogenesis in the hippocampus of LCR/HCR rats. DR results in different responses to a passive avoidance test, and BDNF regulation in LCR and HCR rats.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalBrain Research Bulletin
Volume107
DOIs
StatePublished - 2014

Fingerprint

Brain-Derived Neurotrophic Factor
Feeding Behavior
Short-Term Memory
Hippocampus
Organelle Biogenesis
Nuclear Respiratory Factor 1
Cyclic AMP Response Element-Binding Protein
Chromatin Assembly and Disassembly
Brain
Acetylation
Histones
Oxidoreductases
Quality of Life
Control Groups
Messenger RNA
Proteins

Keywords

  • Brain-derived neurotrophic factor
  • Dietary restriction
  • Epigenetics
  • Exercise capacity
  • Histone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. / Torma, Ferenc; Bori, Zoltan; Koltai, Erika; Felszeghy, Klara; Vacz, Gabriella; Koch, Lauren; Britton, Steven; Boldogh, Istvan; Radak, Zsolt.

In: Brain Research Bulletin, Vol. 107, 2014, p. 54-60.

Research output: Contribution to journalArticle

Torma, Ferenc ; Bori, Zoltan ; Koltai, Erika ; Felszeghy, Klara ; Vacz, Gabriella ; Koch, Lauren ; Britton, Steven ; Boldogh, Istvan ; Radak, Zsolt. / Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats. In: Brain Research Bulletin. 2014 ; Vol. 107. pp. 54-60.
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AU - Felszeghy, Klara

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