TY - JOUR
T1 - Ebola haemorrhagic fever
AU - Feldmann, Heinz
AU - Geisbert, Thomas W.
N1 - Funding Information:
We thank many colleagues in the field for helpful discussions; and the Canadian Institutes of Health Research (CIHR), the intramural (Division of Intramural Research (DIR)), and extramural divisions of the National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and the Public Health Agency of Canada (PHAC), and the Defense Threat Reduction Agency for financial support of our work over the past decade.
PY - 2011
Y1 - 2011
N2 - Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man, designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The exception is the species Reston Ebola virus, which has not been associated with human disease and is found in the Philippines. Ebola virus constitutes an important local public health threat in Africa, with a worldwide effect through imported infections and through the fear of misuse for biological terrorism. Ebola virus is thought to also have a detrimental effect on the great ape population in Africa. Case-fatality rates of the African species in man are as high as 90, with no prophylaxis or treatment available. Ebola virus infections are characterised by immune suppression and a systemic inflammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock.
AB - Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man, designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The exception is the species Reston Ebola virus, which has not been associated with human disease and is found in the Philippines. Ebola virus constitutes an important local public health threat in Africa, with a worldwide effect through imported infections and through the fear of misuse for biological terrorism. Ebola virus is thought to also have a detrimental effect on the great ape population in Africa. Case-fatality rates of the African species in man are as high as 90, with no prophylaxis or treatment available. Ebola virus infections are characterised by immune suppression and a systemic inflammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock.
UR - http://www.scopus.com/inward/record.url?scp=79952363727&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952363727&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(10)60667-8
DO - 10.1016/S0140-6736(10)60667-8
M3 - Review article
C2 - 21084112
AN - SCOPUS:79952363727
SN - 0140-6736
VL - 377
SP - 849
EP - 862
JO - The Lancet
JF - The Lancet
IS - 9768
ER -