Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995

Determinants of survival

Ramses F. Sadek, Ali S. Khan, Gary Stevens, C. J. Peters, Thomas Ksiazek

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7%) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume179
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes

Fingerprint

Ebola Hemorrhagic Fever
Democratic Republic of the Congo
Disease Outbreaks
Survival
Blood Transfusion
Statistical Data Interpretation
Proportional Hazards Models

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995 : Determinants of survival. / Sadek, Ramses F.; Khan, Ali S.; Stevens, Gary; Peters, C. J.; Ksiazek, Thomas.

In: Journal of Infectious Diseases, Vol. 179, No. SUPPL. 1, 1999.

Research output: Contribution to journalArticle

Sadek, Ramses F. ; Khan, Ali S. ; Stevens, Gary ; Peters, C. J. ; Ksiazek, Thomas. / Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995 : Determinants of survival. In: Journal of Infectious Diseases. 1999 ; Vol. 179, No. SUPPL. 1.
@article{ee9869fe853348a686e0b2dbeefbd971,
title = "Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: Determinants of survival",
abstract = "In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7{\%}) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).",
author = "Sadek, {Ramses F.} and Khan, {Ali S.} and Gary Stevens and Peters, {C. J.} and Thomas Ksiazek",
year = "1999",
language = "English (US)",
volume = "179",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995

T2 - Determinants of survival

AU - Sadek, Ramses F.

AU - Khan, Ali S.

AU - Stevens, Gary

AU - Peters, C. J.

AU - Ksiazek, Thomas

PY - 1999

Y1 - 1999

N2 - In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7%) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).

AB - In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo. This study reports the descriptive features of this outbreak along with a statistical analysis of the outbreak data. Proportional hazards analysis was used to examine the effect of age, phase of the outbreak, and sex on the risk of death, and a conditional probability analysis was used to examine the effectiveness of whole blood transfusion from convalescent patients on survival. Two hundred fifty case-patients (80.7%) died. The main predictor of survival in the proportional hazards model was age. No statistical evidence of a survival benefit of transfusion of blood from convalescent patients was evident after adjusting for age, sex, and the days since onset of symptoms (P = .1713).

UR - http://www.scopus.com/inward/record.url?scp=0033035994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033035994&partnerID=8YFLogxK

M3 - Article

VL - 179

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - SUPPL. 1

ER -