Ebola hemorrhagic fever: Evaluation of passive immunotherapy in nonhuman primates

Peter B. Jahrling, Joan B. Geisbert, James R. Swearengen, Thomas Larsen, Thomas Geisbert

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The survival of 7 of 8 patients with Ebola virus (EBOV) infection after transfusions of convalescent-phase blood during a 1995 outbreak of EBOV infection is frequently cited as evidence that passive immunotherapy is a viable treatment option. To test whether whole-blood transfusions were more efficacious than passively administered immunoglobulins or monoclonal antibodies, we transfused convalescent-phase blood from EBOV-immune monkeys into naive animals shortly after challenge with EBOV. Although passively acquired antibody titers comparable to those associated with effective vaccination were obtained, all monkeys that had received transfusions succumbed to infection concurrently with control monkeys. These data cast further doubt on the value of passive immunotherapy for the treatment of EBOV infection.

Original languageEnglish (US)
JournalJournal of Infectious Diseases
Volume196
Issue numberSUPPL. 2
DOIs
StatePublished - Nov 15 2007
Externally publishedYes

Fingerprint

Ebola Hemorrhagic Fever
Passive Immunization
Ebolavirus
Primates
Haplorhini
Blood Transfusion
Disease Outbreaks
Immunoglobulins
Vaccination
Monoclonal Antibodies
Survival
Antibodies
Therapeutics
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Ebola hemorrhagic fever : Evaluation of passive immunotherapy in nonhuman primates. / Jahrling, Peter B.; Geisbert, Joan B.; Swearengen, James R.; Larsen, Thomas; Geisbert, Thomas.

In: Journal of Infectious Diseases, Vol. 196, No. SUPPL. 2, 15.11.2007.

Research output: Contribution to journalArticle

Jahrling, Peter B. ; Geisbert, Joan B. ; Swearengen, James R. ; Larsen, Thomas ; Geisbert, Thomas. / Ebola hemorrhagic fever : Evaluation of passive immunotherapy in nonhuman primates. In: Journal of Infectious Diseases. 2007 ; Vol. 196, No. SUPPL. 2.
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