Ebola virus disease, democratic republic of the Congo, 2014

Carolina Nanclares, Jimmy Kapetshi, Fanshen Lionetto, Olimpia De La Rosa, Jean Jacques Muyembe Tamfun, Miriam Alia, Gary Kobinger, Andrea Bernasconi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.

Original languageEnglish (US)
Pages (from-to)1579-1586
Number of pages8
JournalEmerging infectious diseases
Issue number9
StatePublished - Sep 2016
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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