Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation

Mathieu Iampietro, Rodrigo I. Santos, Ndongala Michel Lubaki, Alexander Bukreyev

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    A better understanding of the mechanisms used by Ebola virus to disable the host immune system and spread the infection are of great importance for development of new therapeutic strategies. We demonstrate that treatment of monocytic cells with Ebola virus shed glycoprotein (GP) promotes their differentiation resulting in increased infection and cell death. The effects were inhibited by blocking Toll-like receptor 4 pathway. In addition, high levels of shed GP were detected in supernatants of cells treated with Ebola vaccines. This study highlights the role of shed GP in Ebola pathogenesis and also in adverse effects associated with Ebola vaccines.

    Original languageEnglish (US)
    Pages (from-to)S327-S334
    JournalThe Journal of infectious diseases
    Volume218
    Issue number5
    DOIs
    StatePublished - Nov 22 2018

    Fingerprint

    Ebolavirus
    Ebola Vaccines
    Toll-Like Receptor 4
    Monocytes
    Glycoproteins
    Infection
    Immune System
    Cell Death
    Therapeutics

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Infectious Diseases

    Cite this

    Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation. / Iampietro, Mathieu; Santos, Rodrigo I.; Lubaki, Ndongala Michel; Bukreyev, Alexander.

    In: The Journal of infectious diseases, Vol. 218, No. 5, 22.11.2018, p. S327-S334.

    Research output: Contribution to journalArticle

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