Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation

Mathieu Iampietro, Rodrigo I. Santos, Ndongala Michel Lubaki, Alexander Bukreyev

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    A better understanding of the mechanisms used by Ebola virus to disable the host immune system and spread the infection are of great importance for development of new therapeutic strategies. We demonstrate that treatment of monocytic cells with Ebola virus shed glycoprotein (GP) promotes their differentiation resulting in increased infection and cell death. The effects were inhibited by blocking Toll-like receptor 4 pathway. In addition, high levels of shed GP were detected in supernatants of cells treated with Ebola vaccines. This study highlights the role of shed GP in Ebola pathogenesis and also in adverse effects associated with Ebola vaccines.

    Original languageEnglish (US)
    Pages (from-to)S327-S334
    JournalJournal of Infectious Diseases
    Volume218
    DOIs
    StatePublished - Nov 22 2018

    Keywords

    • Ebola virus
    • Toll-like receptor.
    • differentiation
    • infection
    • shed GP

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Infectious Diseases

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