TY - JOUR
T1 - Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats
AU - Petronilho, Fabricia
AU - Florentino, Drielly
AU - Silvestre, Fernanda
AU - Danielski, Lucineia Gainski
AU - Nascimento, Diego Zapelini
AU - Vieira, Andriele
AU - Kanis, Luiz Alberto
AU - Fortunato, Jucelia Jeremias
AU - Badawy, Marwa
AU - Barichello, Tatiana
AU - Quevedo, Joao
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/8/21
Y1 - 2015/8/21
N2 - The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.
AB - The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.
KW - acute lung injury
KW - ebselen
KW - inflammation
KW - oxidative damage
KW - pleurisy
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U2 - 10.1007/s10753-015-0113-5
DO - 10.1007/s10753-015-0113-5
M3 - Article
C2 - 25616904
AN - SCOPUS:84937252085
SN - 0360-3997
VL - 38
SP - 1394
EP - 1400
JO - Inflammation
JF - Inflammation
IS - 4
ER -