Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats

Fabricia Petronilho; Drielly Florentino; Fernanda Silvestre; Lucineia Gainski Danielski; Diego Zapelini Nascimento; Andriele Vieira; Luiz Alberto Kanis; Jucelia Jeremias Fortunato; Marwa Badawy; Tatiana Barichello; Joao Quevedo

doi:10.1007/s10753-015-0113-5

Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats

Fabricia Petronilho
, Drielly Florentino
, Fernanda Silvestre
, Lucineia Gainski Danielski
, Diego Zapelini Nascimento
, Andriele Vieira
, Luiz Alberto Kanis
, Jucelia Jeremias Fortunato
, Marwa Badawy
, Tatiana Barichello
, Joao Quevedo

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.

Original language	English (US)
Pages (from-to)	1394-1400
Number of pages	7
Journal	Inflammation
Volume	38
Issue number	4
DOIs	https://doi.org/10.1007/s10753-015-0113-5
State	Published - Aug 21 2015
Externally published	Yes

Keywords

acute lung injury
ebselen
inflammation
oxidative damage
pleurisy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1007/s10753-015-0113-5

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title = "Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats",

abstract = "The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 \% λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.",

keywords = "acute lung injury, ebselen, inflammation, oxidative damage, pleurisy",

author = "Fabricia Petronilho and Drielly Florentino and Fernanda Silvestre and Danielski, \{Lucineia Gainski\} and Nascimento, \{Diego Zapelini\} and Andriele Vieira and Kanis, \{Luiz Alberto\} and Fortunato, \{Jucelia Jeremias\} and Marwa Badawy and Tatiana Barichello and Joao Quevedo",

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year = "2015",

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doi = "10.1007/s10753-015-0113-5",

language = "English (US)",

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T1 - Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats

AU - Petronilho, Fabricia

AU - Florentino, Drielly

AU - Silvestre, Fernanda

AU - Danielski, Lucineia Gainski

AU - Nascimento, Diego Zapelini

AU - Vieira, Andriele

AU - Kanis, Luiz Alberto

AU - Fortunato, Jucelia Jeremias

AU - Badawy, Marwa

AU - Barichello, Tatiana

AU - Quevedo, Joao

PY - 2015/8/21

Y1 - 2015/8/21

N2 - The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.

AB - The study evaluates the role of Ebselen (Eb), an organoselenium compound in animal model of acute lung injury induced by carrageenan (CG). Wistar rats received saline or 2 % λ-carrageenan in the pleural cavity, and treatment with Eb (50 mg/kg intragastrically) or dexamethasone (Dx) (0.5 mg/kg intraperitoneal) after CG administration. After 4 h, rats were euthanized and the pleural exudate removed for analysis of the total cell count, total protein, lactate dehydrogenase, and nitrite/nitrate. Moreover, lung tissue were removed to verify the myeloperoxidase activity and oxidative damage. Eb showed anti-inflammatory activity by inhibiting leukocyte influx, myeloperoxidase activity, and nitrite/nitrate concentration. Eb presented with an anti-inflammatory activity similar to Dx and an antioxidant activity better than Dx. This study suggests that Eb plays an important role against the oxidative damage associated with anti-inflammatory activity in animal model of acute lung injury, proving to be similar or potentially more effective than Dx.

KW - acute lung injury

KW - ebselen

KW - inflammation

KW - oxidative damage

KW - pleurisy

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DO - 10.1007/s10753-015-0113-5

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SN - 0360-3997

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ER -

Ebselen Attenuates Lung Injury in Experimental Model of Carrageenan-Induced Pleurisy in Rats

Abstract

Keywords

ASJC Scopus subject areas

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