TY - JOUR
T1 - EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations
AU - Yen, A.
AU - Fearneyhough, P.
AU - Raimer, S. S.
AU - Hudnall, S. D.
N1 - Funding Information:
OIqTHO This article is made possible through an educational grant from the Dermatological Division, Ortho Pharmaceutical Corporation. From the Departments of dermatology a and Pathology? University of Texas Medical Branch, Galveston. Reprint requests: S. David Hudnall, MD, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0741. Copyright © 1996 by the American Academy of Dermatology, Inc. 0190-9622/96 $5.00 + 0 16/4/76139
PY - 1997
Y1 - 1997
N2 - The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.
AB - The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.
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U2 - 10.1016/S0190-9622(97)80413-6
DO - 10.1016/S0190-9622(97)80413-6
M3 - Article
C2 - 9039215
AN - SCOPUS:0031041405
VL - 36
SP - 342
EP - 346
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 2 SUPPL.
ER -