EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations

A. Yen, P. Fearneyhough, S. S. Raimer, S. D. Hudnall

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.

Original languageEnglish
Pages (from-to)342-346
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume36
Issue number2 SUPPL.
StatePublished - 1997

Fingerprint

Histiocytic Necrotizing Lymphadenitis
Skin Manifestations
Human Herpesvirus 4
Chills
Skin
Myalgia
DNA-Directed DNA Polymerase
In Situ Hybridization
Publications
Lymphoma
Membrane Proteins
Fever
Necrosis
Lymph Nodes
Lymphocytes
RNA
Staining and Labeling
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Dermatology

Cite this

Yen, A., Fearneyhough, P., Raimer, S. S., & Hudnall, S. D. (1997). EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. Journal of the American Academy of Dermatology, 36(2 SUPPL.), 342-346.

EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. / Yen, A.; Fearneyhough, P.; Raimer, S. S.; Hudnall, S. D.

In: Journal of the American Academy of Dermatology, Vol. 36, No. 2 SUPPL., 1997, p. 342-346.

Research output: Contribution to journalArticle

Yen, A, Fearneyhough, P, Raimer, SS & Hudnall, SD 1997, 'EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations', Journal of the American Academy of Dermatology, vol. 36, no. 2 SUPPL., pp. 342-346.
Yen, A. ; Fearneyhough, P. ; Raimer, S. S. ; Hudnall, S. D. / EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. In: Journal of the American Academy of Dermatology. 1997 ; Vol. 36, No. 2 SUPPL. pp. 342-346.
@article{7c4117e4802349068476717363f2c084,
title = "EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations",
abstract = "The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16{\%} to 40{\%} of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.",
author = "A. Yen and P. Fearneyhough and Raimer, {S. S.} and Hudnall, {S. D.}",
year = "1997",
language = "English",
volume = "36",
pages = "342--346",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "2 SUPPL.",

}

TY - JOUR

T1 - EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations

AU - Yen, A.

AU - Fearneyhough, P.

AU - Raimer, S. S.

AU - Hudnall, S. D.

PY - 1997

Y1 - 1997

N2 - The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.

AB - The clinical and pathologic findings of Kikuchi's histiocytic necrotizing lymphadenitis may mimic those of malignant lymphoma. We describe a 6-year-old boy with generalized lymphadenopathy, spiking fever, chills, myalgias, malaise, and erythematous, crusted papules. Although cutaneous manifestations have been noted in 16% to 40% of patients with histiocytic necrotizing lymphadenitis, only three publications described skin lesions. The skin lesions and affected lymph nodes revealed histiocytic aggregates, atypical lymphoid cells, karyorrhectic debris, and patchy necrosis. Spontaneous resolution occurred in 2 months. Results of serologic studies, Epstein-Barr virus (EBV) latent membrane protein immunoperoxidase staining. EBER-1 RNA in-situ hybridization, and EBV EBNA-1 DNA polymerase chain reaction implicate EBV as the causative agent.

UR - http://www.scopus.com/inward/record.url?scp=0031041405&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031041405&partnerID=8YFLogxK

M3 - Article

C2 - 9039215

AN - SCOPUS:0031041405

VL - 36

SP - 342

EP - 346

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 2 SUPPL.

ER -