Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury

Xianzeng Liu, Kyungsoon Chung, Jin Chung

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

At various times after spinal nerve injury, dorsal root ganglia (DRGs) from injured segments were removed with attached dorsal roots and spinal nerves. In an in vitro recording chamber, spontaneously active units were recorded from teased dorsal root fascicles. Sustained spontaneous activity could first be recorded at 13 h after the ligation, but adrenergic sensitivity did not develop until 24 h after the injury. Almost all recorded activity originated from the DRG. Thus, the DRG is the most common site for ectopic discharge generation after spinal nerve injury and separate mechanisms seem to be involved in the development of ectopic discharges and adrenergic sensitivity. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)244-247
Number of pages4
JournalBrain Research
Volume849
Issue number1-2
DOIs
StatePublished - Dec 4 1999

Fingerprint

Spinal Injuries
Spinal Nerves
Spinal Ganglia
Sensory Receptor Cells
Adrenergic Agents
Spinal Nerve Roots
Ligation
Wounds and Injuries

Keywords

  • DRG
  • Neuropathic pain
  • Spontaneous activity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury. / Liu, Xianzeng; Chung, Kyungsoon; Chung, Jin.

In: Brain Research, Vol. 849, No. 1-2, 04.12.1999, p. 244-247.

Research output: Contribution to journalArticle

Liu, Xianzeng ; Chung, Kyungsoon ; Chung, Jin. / Ectopic discharges and adrenergic sensitivity of sensory neurons after spinal nerve injury. In: Brain Research. 1999 ; Vol. 849, No. 1-2. pp. 244-247.
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