Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat

Yong Chen, Yousheng Shu, Zhiqi Zhao

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

THE possibility that ectopic purinergic sensitivity develops following peripheral nerve injury was investigated in chronic constriction injury (CCI). Spontaneous firing of A-fibers originated from the injury site or from sensory endings of afferents in the contralateral sciatic nerve. ATP injected intravenously excited most of the injured fibers whereas none of the contralateral afferents responded to ATP. The ATP-induced effect was blocked by the P2 receptor antagonist reactive blue 2, but not the P1 receptor antagonist aminophylline. Neither the α-adrenoreceptor antagonist phentolamine nor the cyclooxygenase inhibitor indomethacin attenuated the ATP-evoked effect. We conclude that a novel ectopic purinergic sensitivity mediated by P2 receptors develops at sites of the CCI of nerves in the rat, which may contribute to neuropathic pain.

Original languageEnglish (US)
Pages (from-to)2779-2782
Number of pages4
JournalNeuroReport
Volume10
Issue number13
DOIs
StatePublished - Sep 9 1999

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Keywords

  • ATP
  • Chemosensitivity
  • Chronic constriction injury
  • Nerve injury
  • Neuropathic pain
  • P2 receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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