Effect Modification and Interaction Terms: It Takes Two to Tango

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    4 Scopus citations


    In this Investigators' Corner I look more deeply into the previously discussed phenomenon of effect modification. I revisit an explanation and examples of the phenomenon and then examine how to account for it statistically. Specifically, I show, in detail, how to write a regression equation that includes interaction terms that account for the effect modification. Finally, I look at interpretation of regression coefficients both with and without the presence of effect modification, and the associated interaction terms.

    Original languageEnglish (US)
    Pages (from-to)899-902
    Number of pages4
    JournalJournal of Foot and Ankle Surgery
    Issue number4
    StatePublished - Jul 1 2016


    • confounding
    • effect modification
    • interaction terms
    • multivariate analysis
    • regression

    ASJC Scopus subject areas

    • Surgery
    • Orthopedics and Sports Medicine


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