Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

Yan Shi Guo, James C. Thompson, Pomila Singh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalRegulatory Peptides
Volume24
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • Bombesin
  • Gastrin
  • Somatostatin
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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