Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

Yan Shi Guo, James C. Thompson, Pomila Singh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalRegulatory Peptides
Volume24
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Aminobutyrates
Bombesin
Gastrins
Somatostatin
Rats
Stomach
gamma-Aminobutyric Acid

Keywords

  • Bombesin
  • Gastrin
  • Somatostatin
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach. / Guo, Yan Shi; Thompson, James C.; Singh, Pomila.

In: Regulatory Peptides, Vol. 24, No. 2, 1989, p. 179-186.

Research output: Contribution to journalArticle

@article{ccb13c0c22944c95a9f954b9a52214a3,
title = "Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach",
abstract = "The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.",
keywords = "Bombesin, Gastrin, Somatostatin, γ-aminobutyric acid",
author = "Guo, {Yan Shi} and Thompson, {James C.} and Pomila Singh",
year = "1989",
doi = "10.1016/0167-0115(89)90236-X",
language = "English (US)",
volume = "24",
pages = "179--186",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Effect of γ-aminobutyric acid on bombesin-evoked release of somatostatin and gastrin from isolated rat stomach

AU - Guo, Yan Shi

AU - Thompson, James C.

AU - Singh, Pomila

PY - 1989

Y1 - 1989

N2 - The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

AB - The effect of γ-aminobutyric acid (GABA) on basal and bombesin (BBS)-stimulated release of somatostatin (SLI) and gastrin from isolated perfused rat stomach was examined. In the control study, BBS at a dose of 10 nM significantly stimulated release of SLI and gastrin. Infusion of GABA (1-1000 nM) caused a depression of SLI release induced by BBS (10 nM) in a dose-dependent fashion. However, at doses used in this study GABA had no effect on either basal level of SLI and gastrin or BBS-elicited gastrin release. These results indicate that GABA can specifically modulate BBS-induced SLI release from rat stomach.

KW - Bombesin

KW - Gastrin

KW - Somatostatin

KW - γ-aminobutyric acid

UR - http://www.scopus.com/inward/record.url?scp=0024538253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024538253&partnerID=8YFLogxK

U2 - 10.1016/0167-0115(89)90236-X

DO - 10.1016/0167-0115(89)90236-X

M3 - Article

C2 - 2564210

AN - SCOPUS:0024538253

VL - 24

SP - 179

EP - 186

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 2

ER -