Effect of 5-HT3 receptor antagonist (ondansetron) on functioning human pancreatic carcinoid cells

J. Ishizuka, A. C. Hsieh, C. M. Townsend, J. C. Thompson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

5-Hydroxytryptamine (5-HT) is a mitogen for selected cell types. We have reported that 5-HT is an autocrine growth factor for functioning human pancreatic carcinoid (BON) cells; autocrine growth effect is transmitted by 5-HT1A but not 5-HT 1C 2 receptors, activation of which decreases cyclic AMP production through a pertussis toxin-sensitive inhibitory GTP-binding protein. In this study, the effect of 5-HT3 receptor antagonist, ondansetron, on BON was examined. Ondansetron did not affect growth of BON cells and also affected neither stimulation of phosphatidylinositol hydrolysis or inhibition of cyclic AMP production evoked by 5-HT in BON cells. Ondansetron, however, inhibited mobilization of intracellular calcium evoked by 5-HT. Present findings suggest that BON cells possess 5-HT3 receptors, but their roles in pancreatic carcinoid cells are still unknown.

Original languageEnglish (US)
Pages (from-to)221-225
Number of pages5
JournalSurgical oncology
Volume2
Issue number4
DOIs
StatePublished - Aug 1993

Keywords

  • 5-hydroxytryptamine
  • Ca
  • cAMP
  • carcinoid cells
  • ondansetron
  • phosphatidylinositol hydrolysis

ASJC Scopus subject areas

  • Surgery
  • Oncology

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