Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs

Masaki Fujimura, Tsuguo Sakamoto, Felix Lluis, R. Daniel Beauchamp, Courtney Townsend, George H. Greeley, James C. Thompson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. The gallbladder contraction was monitored by a strain-gauge force transducer that was chronically sutured onto the serosal surface of the gallbladder. The results of this study show that proglumide, given as an intravenous bolus (2.5, 5, 10, 20, and 40 mg/kg) or as a continuous intravenous infusion (150 or 300 mg/kg/h, 10 min), can block the stimulatory action of CCK in a dose-related manner. Bolus administration of proglumide resulted in a transient inhibition, whereas continuous infusion of proglumide resulted in a prolonged antagonism of CCK-stimulated gallbladder contraction. Review of the data leads to the conclusion that the antagonistic action of intravenously administered proglumide on CCK-stimulated gallbladder contraction may be characterized as rapid and reversible.

Original languageEnglish (US)
Pages (from-to)94-100
Number of pages7
JournalNeuroSignals
Volume1
Issue number2
DOIs
StatePublished - 1992

Keywords

  • Cholecystokinin
  • Gallbladder
  • Proglumide
  • Strain-gauge force transducer

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Neurology

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