Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs.

M. Fujimura, T. Sakamoto, F. Lluis, R. D. Beauchamp, C. M. Townsend, G. H. Greeley, J. C. Thompson

    Research output: Contribution to journalArticle

    Abstract

    The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. The gallbladder contraction was monitored by a strain-gauge force transducer that was chronically sutured onto the serosal surface of the gallbladder. The results of this study show that proglumide, given as an intravenous bolus (2.5, 5, 10, 20, and 40 mg/kg) or as a continuous intravenous infusion (150 or 300 mg/kg/h, 10 min), can block the stimulatory action of CCK in a dose-related manner. Bolus administration of proglumide resulted in a transient inhibition, whereas continuous infusion of proglumide resulted in a prolonged antagonism of CCK-stimulated gallbladder contraction. Review of the data leads to the conclusion that the antagonistic action of intravenously administered proglumide on CCK-stimulated gallbladder contraction may be characterized as rapid and reversible.

    Original languageEnglish (US)
    Pages (from-to)94-100
    Number of pages7
    JournalBiological Signals
    Volume1
    Issue number2
    StatePublished - Mar 1992

    Fingerprint

    Proglumide
    Cholecystokinin
    Gallbladder
    Dogs
    Strain gages
    Transducers
    Intravenous Infusions
    cholecystokinin 8

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Fujimura, M., Sakamoto, T., Lluis, F., Beauchamp, R. D., Townsend, C. M., Greeley, G. H., & Thompson, J. C. (1992). Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs. Biological Signals, 1(2), 94-100.

    Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs. / Fujimura, M.; Sakamoto, T.; Lluis, F.; Beauchamp, R. D.; Townsend, C. M.; Greeley, G. H.; Thompson, J. C.

    In: Biological Signals, Vol. 1, No. 2, 03.1992, p. 94-100.

    Research output: Contribution to journalArticle

    Fujimura, M, Sakamoto, T, Lluis, F, Beauchamp, RD, Townsend, CM, Greeley, GH & Thompson, JC 1992, 'Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs.', Biological Signals, vol. 1, no. 2, pp. 94-100.
    Fujimura, M. ; Sakamoto, T. ; Lluis, F. ; Beauchamp, R. D. ; Townsend, C. M. ; Greeley, G. H. ; Thompson, J. C. / Effect of a cholecystokinin antagonist, proglumide, on cholecystokinin-8-induced gallbladder contraction in conscious dogs. In: Biological Signals. 1992 ; Vol. 1, No. 2. pp. 94-100.
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    abstract = "The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. The gallbladder contraction was monitored by a strain-gauge force transducer that was chronically sutured onto the serosal surface of the gallbladder. The results of this study show that proglumide, given as an intravenous bolus (2.5, 5, 10, 20, and 40 mg/kg) or as a continuous intravenous infusion (150 or 300 mg/kg/h, 10 min), can block the stimulatory action of CCK in a dose-related manner. Bolus administration of proglumide resulted in a transient inhibition, whereas continuous infusion of proglumide resulted in a prolonged antagonism of CCK-stimulated gallbladder contraction. Review of the data leads to the conclusion that the antagonistic action of intravenously administered proglumide on CCK-stimulated gallbladder contraction may be characterized as rapid and reversible.",
    author = "M. Fujimura and T. Sakamoto and F. Lluis and Beauchamp, {R. D.} and Townsend, {C. M.} and Greeley, {G. H.} and Thompson, {J. C.}",
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    AU - Sakamoto, T.

    AU - Lluis, F.

    AU - Beauchamp, R. D.

    AU - Townsend, C. M.

    AU - Greeley, G. H.

    AU - Thompson, J. C.

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    AB - The objective of this study was to characterize the effect of proglumide, a cholecystokinin (CCK) antagonist, on gallbladder contraction stimulated by CCK in conscious dogs. The gallbladder contraction was monitored by a strain-gauge force transducer that was chronically sutured onto the serosal surface of the gallbladder. The results of this study show that proglumide, given as an intravenous bolus (2.5, 5, 10, 20, and 40 mg/kg) or as a continuous intravenous infusion (150 or 300 mg/kg/h, 10 min), can block the stimulatory action of CCK in a dose-related manner. Bolus administration of proglumide resulted in a transient inhibition, whereas continuous infusion of proglumide resulted in a prolonged antagonism of CCK-stimulated gallbladder contraction. Review of the data leads to the conclusion that the antagonistic action of intravenously administered proglumide on CCK-stimulated gallbladder contraction may be characterized as rapid and reversible.

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