Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model

G. S. Raju, Guillermo Gomez, S. Y. Xiao, I. Ahmed, D. Brining, M. S. Bhutani, A. N. Kalloo, P. J. Pasricha

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background and Study Aims: Attempts to address the problem of injury to the pancreas by indwelling pancreatic stents are limited by our lack of knowledge of the pathogenesis of stent-induced injury and its relationship to stent morphology and the duration of stenting. The aim of our study was to evaluate pancreatic injury induced by 1 week of stenting with a 5F indwelling pancreatic stent of novel design, the "wing stent." Methods: Pancreatic stents (5F) were placed surgically in eight dogs; wing stents (WS-5F) were used in four dogs and conventional stents (CS-5F) in another four. Two dogs underwent duodenotomy without stent placement (controls). The pancreas was harvested for microscopy at 1 week. A pathologist who was unaware of the source of the specimens graded the pancreatic injury. Results: Although pancreatic injury was observed in both the CS-5F and WS-5F groups after 1 week of indwelling pancreatic stenting, it was considerably less severe in the WS-5F group compared with the CS-5F group (1.01 ± 0.10 vs. 1.63 ± 0.14, P < 0.01). All components of pancreatic injury were affected, with the most dramatic differences noted in inflammation, fibrosis, and edema. The differences were most marked in the stented segment (P < 0.001) and in the upstream segment of the pancreas (P < 0.05). Conclusions: Indwelling conventional pancreatic stents can cause significant pancreatic injury even when left in place for only 1 week. A wing design can significantly ameliorate stent-induced changes.

Original languageEnglish (US)
Pages (from-to)260-265
Number of pages6
JournalEndoscopy
Volume38
Issue number3
DOIs
StatePublished - Mar 2006

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Stents
Canidae
Wounds and Injuries
Pancreas
Dogs
Microscopy
Edema
Fibrosis
Inflammation

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Raju, G. S., Gomez, G., Xiao, S. Y., Ahmed, I., Brining, D., Bhutani, M. S., ... Pasricha, P. J. (2006). Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model. Endoscopy, 38(3), 260-265. https://doi.org/10.1055/s-2006-925052

Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model. / Raju, G. S.; Gomez, Guillermo; Xiao, S. Y.; Ahmed, I.; Brining, D.; Bhutani, M. S.; Kalloo, A. N.; Pasricha, P. J.

In: Endoscopy, Vol. 38, No. 3, 03.2006, p. 260-265.

Research output: Contribution to journalArticle

Raju, GS, Gomez, G, Xiao, SY, Ahmed, I, Brining, D, Bhutani, MS, Kalloo, AN & Pasricha, PJ 2006, 'Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model', Endoscopy, vol. 38, no. 3, pp. 260-265. https://doi.org/10.1055/s-2006-925052
Raju GS, Gomez G, Xiao SY, Ahmed I, Brining D, Bhutani MS et al. Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model. Endoscopy. 2006 Mar;38(3):260-265. https://doi.org/10.1055/s-2006-925052
Raju, G. S. ; Gomez, Guillermo ; Xiao, S. Y. ; Ahmed, I. ; Brining, D. ; Bhutani, M. S. ; Kalloo, A. N. ; Pasricha, P. J. / Effect of a novel pancreatic stent design on short-term pancreatic injury in a canine model. In: Endoscopy. 2006 ; Vol. 38, No. 3. pp. 260-265.
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