Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat

D. Fanini, N. M. Trieff, V-M Ramanujam, A. E. Ahmed, P. M. Adams

Research output: Contribution to journalArticle

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Abstract

The effects of acute exposure to acrylonitrile (ACN), 10, 20, or 40 mg/kg by gavage, on the ability of metrazol (MTZ) to induce seizures was studied in adult, male Sprague-Dawley rats. The frequency of seizure occurrence and the frequency of a lethal seizure was greater when the high ACN dosage was given in combination with metrazol. This dosage of ACN was not lethal when given alone. Examination of brain tissue in these animals revealed no difference in cyanide levels when MTZ was combined with ACN. However, brain cytochrome c was significantly lower in animals given ACN + MTZ and brain cholinesterase was significantly higher. These results suggest that the enhanced lethality occurring in animals exposed to the combination of ACN + MTZ is not due to cyanide, a metabolic product of ACN, but rather to a potentiation of other effects of ACN perhaps involving cholinergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalNeuroToxicology
Volume6
Issue number1
StatePublished - 1985

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Acrylonitrile
Pentylenetetrazole
Rats
Seizures
Brain
Animals
Cyanides
Cholinesterases
Cytochromes c
Synaptic Transmission
Cholinergic Agents
Sprague Dawley Rats
Tissue

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Fanini, D., Trieff, N. M., Ramanujam, V-M., Ahmed, A. E., & Adams, P. M. (1985). Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. NeuroToxicology, 6(1), 29-34.

Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. / Fanini, D.; Trieff, N. M.; Ramanujam, V-M; Ahmed, A. E.; Adams, P. M.

In: NeuroToxicology, Vol. 6, No. 1, 1985, p. 29-34.

Research output: Contribution to journalArticle

Fanini, D, Trieff, NM, Ramanujam, V-M, Ahmed, AE & Adams, PM 1985, 'Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat', NeuroToxicology, vol. 6, no. 1, pp. 29-34.
Fanini, D. ; Trieff, N. M. ; Ramanujam, V-M ; Ahmed, A. E. ; Adams, P. M. / Effect of acute acrylonitrile exposure on metrazol induced seizures in the rat. In: NeuroToxicology. 1985 ; Vol. 6, No. 1. pp. 29-34.
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