Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage

Michel T. Torbey, Till Karsten Hauser, Anish Bhardwaj, Michael A. Williams, John A. Ulatowski, Marek A. Mirski, Alexander Y. Razumovsky

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background and Purpose - Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of age on cerebral blood flow velocity changes after subarachnoid hemorrhage and constructed an age-adjusted predictive model of cerebral blood flow velocity in subarachnoid hemorrhage patients. Methods - We identified patients with aneurysmal subarachnoid hemorrhage admitted between 1991 and 1999 with a prospective transcranial Doppler database. Eighty-one patients, with complete medical records and transcranial Doppler examinations of the vessels of interest, were included. Patients were subdivided into 2 groups by age: younger, <68 years of age (n = 47) and older, ≥68 years of age (n = 34). Maximum mean flow velocity and incidence of symptomatic vasospasm were reported. Linear and nonlinear regression analyses were performed. Results - Middle cerebral artery and internal carotid artery mean flow velocity were lower in older patients (median 76 versus 114 cm/s and 76 versus 126 cm/s, respectively; P<0.003). Incidence of symptomatic vasospasm was lower in older patients (44% versus 66%; P = 0.05). Older patients developed symptomatic vasospasm at lower middle cerebral artery (median 57 versus 103 cm/s; P = 0.04) and internal carotid artery (median 54 versus 81 cm/s, P = 0.02) mean flow velocity. Relationship between middle cerebral artery and internal carotid artery mean flow velocity and age was quadratic (ANOVA, P<0.0001). Conclusions - Older patients have a lower incidence of symptomatic vasospasm, and such vasospasm develops at lower cerebral blood flow velocity than younger patients. A quadratic relationship was found between age and cerebral blood flow velocity. This model could be used to create an age-adjusted nomogram that might improve diagnostic capabilities of transcranial Doppler.

Original languageEnglish (US)
Pages (from-to)2005-2011
Number of pages7
JournalStroke
Volume32
Issue number9
StatePublished - 2001
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Blood Flow Velocity
Subarachnoid Hemorrhage
Incidence
Middle Cerebral Artery
Internal Carotid Artery
Nomograms
Medical Records
Linear Models
Analysis of Variance
Age Groups

Keywords

  • Aging
  • Cerebral angiography
  • Doppler
  • Subarachnoid hemorrhage
  • Transcranial
  • Ultrasonography
  • Vasospasm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Torbey, M. T., Hauser, T. K., Bhardwaj, A., Williams, M. A., Ulatowski, J. A., Mirski, M. A., & Razumovsky, A. Y. (2001). Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage. Stroke, 32(9), 2005-2011.

Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage. / Torbey, Michel T.; Hauser, Till Karsten; Bhardwaj, Anish; Williams, Michael A.; Ulatowski, John A.; Mirski, Marek A.; Razumovsky, Alexander Y.

In: Stroke, Vol. 32, No. 9, 2001, p. 2005-2011.

Research output: Contribution to journalArticle

Torbey, MT, Hauser, TK, Bhardwaj, A, Williams, MA, Ulatowski, JA, Mirski, MA & Razumovsky, AY 2001, 'Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage', Stroke, vol. 32, no. 9, pp. 2005-2011.
Torbey MT, Hauser TK, Bhardwaj A, Williams MA, Ulatowski JA, Mirski MA et al. Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2001;32(9):2005-2011.
Torbey, Michel T. ; Hauser, Till Karsten ; Bhardwaj, Anish ; Williams, Michael A. ; Ulatowski, John A. ; Mirski, Marek A. ; Razumovsky, Alexander Y. / Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage. In: Stroke. 2001 ; Vol. 32, No. 9. pp. 2005-2011.
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abstract = "Background and Purpose - Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of age on cerebral blood flow velocity changes after subarachnoid hemorrhage and constructed an age-adjusted predictive model of cerebral blood flow velocity in subarachnoid hemorrhage patients. Methods - We identified patients with aneurysmal subarachnoid hemorrhage admitted between 1991 and 1999 with a prospective transcranial Doppler database. Eighty-one patients, with complete medical records and transcranial Doppler examinations of the vessels of interest, were included. Patients were subdivided into 2 groups by age: younger, <68 years of age (n = 47) and older, ≥68 years of age (n = 34). Maximum mean flow velocity and incidence of symptomatic vasospasm were reported. Linear and nonlinear regression analyses were performed. Results - Middle cerebral artery and internal carotid artery mean flow velocity were lower in older patients (median 76 versus 114 cm/s and 76 versus 126 cm/s, respectively; P<0.003). Incidence of symptomatic vasospasm was lower in older patients (44{\%} versus 66{\%}; P = 0.05). Older patients developed symptomatic vasospasm at lower middle cerebral artery (median 57 versus 103 cm/s; P = 0.04) and internal carotid artery (median 54 versus 81 cm/s, P = 0.02) mean flow velocity. Relationship between middle cerebral artery and internal carotid artery mean flow velocity and age was quadratic (ANOVA, P<0.0001). Conclusions - Older patients have a lower incidence of symptomatic vasospasm, and such vasospasm develops at lower cerebral blood flow velocity than younger patients. A quadratic relationship was found between age and cerebral blood flow velocity. This model could be used to create an age-adjusted nomogram that might improve diagnostic capabilities of transcranial Doppler.",
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T1 - Effect of age on cerebral blood flow velocity and incidence of vasospasm after aneurysmal subarachnoid hemorrhage

AU - Torbey, Michel T.

AU - Hauser, Till Karsten

AU - Bhardwaj, Anish

AU - Williams, Michael A.

AU - Ulatowski, John A.

AU - Mirski, Marek A.

AU - Razumovsky, Alexander Y.

PY - 2001

Y1 - 2001

N2 - Background and Purpose - Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of age on cerebral blood flow velocity changes after subarachnoid hemorrhage and constructed an age-adjusted predictive model of cerebral blood flow velocity in subarachnoid hemorrhage patients. Methods - We identified patients with aneurysmal subarachnoid hemorrhage admitted between 1991 and 1999 with a prospective transcranial Doppler database. Eighty-one patients, with complete medical records and transcranial Doppler examinations of the vessels of interest, were included. Patients were subdivided into 2 groups by age: younger, <68 years of age (n = 47) and older, ≥68 years of age (n = 34). Maximum mean flow velocity and incidence of symptomatic vasospasm were reported. Linear and nonlinear regression analyses were performed. Results - Middle cerebral artery and internal carotid artery mean flow velocity were lower in older patients (median 76 versus 114 cm/s and 76 versus 126 cm/s, respectively; P<0.003). Incidence of symptomatic vasospasm was lower in older patients (44% versus 66%; P = 0.05). Older patients developed symptomatic vasospasm at lower middle cerebral artery (median 57 versus 103 cm/s; P = 0.04) and internal carotid artery (median 54 versus 81 cm/s, P = 0.02) mean flow velocity. Relationship between middle cerebral artery and internal carotid artery mean flow velocity and age was quadratic (ANOVA, P<0.0001). Conclusions - Older patients have a lower incidence of symptomatic vasospasm, and such vasospasm develops at lower cerebral blood flow velocity than younger patients. A quadratic relationship was found between age and cerebral blood flow velocity. This model could be used to create an age-adjusted nomogram that might improve diagnostic capabilities of transcranial Doppler.

AB - Background and Purpose - Current transcranial Doppler criteria for vasospasm after aneurysmal subarachnoid hemorrhage are not age specific. We analyzed the effect of age on cerebral blood flow velocity changes after subarachnoid hemorrhage and constructed an age-adjusted predictive model of cerebral blood flow velocity in subarachnoid hemorrhage patients. Methods - We identified patients with aneurysmal subarachnoid hemorrhage admitted between 1991 and 1999 with a prospective transcranial Doppler database. Eighty-one patients, with complete medical records and transcranial Doppler examinations of the vessels of interest, were included. Patients were subdivided into 2 groups by age: younger, <68 years of age (n = 47) and older, ≥68 years of age (n = 34). Maximum mean flow velocity and incidence of symptomatic vasospasm were reported. Linear and nonlinear regression analyses were performed. Results - Middle cerebral artery and internal carotid artery mean flow velocity were lower in older patients (median 76 versus 114 cm/s and 76 versus 126 cm/s, respectively; P<0.003). Incidence of symptomatic vasospasm was lower in older patients (44% versus 66%; P = 0.05). Older patients developed symptomatic vasospasm at lower middle cerebral artery (median 57 versus 103 cm/s; P = 0.04) and internal carotid artery (median 54 versus 81 cm/s, P = 0.02) mean flow velocity. Relationship between middle cerebral artery and internal carotid artery mean flow velocity and age was quadratic (ANOVA, P<0.0001). Conclusions - Older patients have a lower incidence of symptomatic vasospasm, and such vasospasm develops at lower cerebral blood flow velocity than younger patients. A quadratic relationship was found between age and cerebral blood flow velocity. This model could be used to create an age-adjusted nomogram that might improve diagnostic capabilities of transcranial Doppler.

KW - Aging

KW - Cerebral angiography

KW - Doppler

KW - Subarachnoid hemorrhage

KW - Transcranial

KW - Ultrasonography

KW - Vasospasm

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VL - 32

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JO - Stroke

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SN - 0039-2499

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