TY - JOUR
T1 - Effect of aging on pancreatic secretion in rats
AU - Khalil, Talaat
AU - Fujimura, Masaki
AU - Townsend, Courtney M.
AU - Greeley, George H.
AU - Thompson, James C.
N1 - Funding Information:
Presented ~t the 25th Annual Meeting of the Societyf or Surgeryo f the Alimentary Tract, New Orlem~, Louisiana,M ay 22-23, 1984, From the Department of Surge~, The University of Texas Medical Branch, Galveston, Texas. Suppoded in part by grants from the Natlcmal Institutes
PY - 1985/1
Y1 - 1985/1
N2 - We have characterized the effects of aging on the pancreatic exocrine secretory response to the normal stimulatory hormones, secretin, and cholecystokinin. Young (6 month old) and aged (26 months old) male Sprague-Dawley rats were prepared with pancreatic fistulas and challenged with different doses of secretin (0.03, 0.06, and 0.12 nmol/kg) and cholecystokinin-8 (0.3, 0.6, and 1.2 nmol/kg) intravenously. The pancreatic secretion was measured for volume and bicarbonate and protein outputs. Our results show that in aged rats, the basal pancreatic secretion volume and protein and bicarbonate outputs were significantly reduced, and the pancreatic secretion volume and protein and bicarbonate responses to graded doses of secretin or cholecystokinin-8 were significantly reduced. This study demonstrates that pancreatic exocrine function in rats diminishes with age.
AB - We have characterized the effects of aging on the pancreatic exocrine secretory response to the normal stimulatory hormones, secretin, and cholecystokinin. Young (6 month old) and aged (26 months old) male Sprague-Dawley rats were prepared with pancreatic fistulas and challenged with different doses of secretin (0.03, 0.06, and 0.12 nmol/kg) and cholecystokinin-8 (0.3, 0.6, and 1.2 nmol/kg) intravenously. The pancreatic secretion was measured for volume and bicarbonate and protein outputs. Our results show that in aged rats, the basal pancreatic secretion volume and protein and bicarbonate outputs were significantly reduced, and the pancreatic secretion volume and protein and bicarbonate responses to graded doses of secretin or cholecystokinin-8 were significantly reduced. This study demonstrates that pancreatic exocrine function in rats diminishes with age.
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U2 - 10.1016/S0002-9610(85)80020-9
DO - 10.1016/S0002-9610(85)80020-9
M3 - Article
C2 - 3966629
AN - SCOPUS:0021956790
SN - 0002-9610
VL - 149
SP - 120
EP - 125
JO - The American Journal of Surgery
JF - The American Journal of Surgery
IS - 1
ER -