Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats

P. Muriel, J. Bolanos, J. M. Barral, G. Torres

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of α-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCl4-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca2+-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80,000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of α-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalPharmacology
Volume48
Issue number1
StatePublished - 1994
Externally publishedYes

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Keywords

  • ATPases
  • Carbon tetrachloride
  • Cirrhosis
  • Erythrocytes
  • Lipids
  • Liver injury
  • Wistar rats

ASJC Scopus subject areas

  • Pharmacology

Cite this

Muriel, P., Bolanos, J., Barral, J. M., & Torres, G. (1994). Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats. Pharmacology, 48(1), 63-68.