Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats

Pablo Muriel, Javier Bolaños, Jose M. Barral, Gustavo Torres

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    Interferons are recognized to inhibit collagen production. Since fibrosis has been associated with liver dysfunction, we investigated the effects of α-interferon on the function and lipid composition of hepatocyte and erythrocyte plasma membranes derived from CCLl-cirrhotic male Wistar rats. In both cell types, CCl4 decreased Na+/K+ and Ca2+-ATPase activity and increased the cholesterol to phospholipids (CH/PL) ratio (p < 0.05). Administration of interferon (80, 000 IU/kg s.c. for 8 weeks) increased survival from 40 to 90%, and preserved normal ATPase activity and CH/PL ratio. Our results show that administration of α-interferon to CCl4-cirrhotic rats improves survival, and liver and erythrocyte membrane function and composition, probably as a result of its antifibrogenic effect.

    Original languageEnglish (US)
    Pages (from-to)63-68
    Number of pages6
    JournalPharmacology
    Volume48
    Issue number1
    DOIs
    StatePublished - Jan 1 1994

    Keywords

    • ATPases
    • Carbon tetrachloride
    • Cirrhosis
    • Erythrocytes
    • Lipids
    • Liver injury
    • Wistar rats

    ASJC Scopus subject areas

    • Pharmacology

    Fingerprint Dive into the research topics of 'Effect of alpha-interferon on erythrocyte and hepatocyte plasma membranes derived from cirrhotic rats'. Together they form a unique fingerprint.

  • Cite this