Effect of an experimental rhinovirus 16 infection on airway mediator response to antigen

William W. Busse, William J. Calhoun, Elliot C. Dick

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Viral respiratory infections provoke wheezing in many patients with asthma. It is our hypothesis that viral respiratory infections enhance the airway inflam-matory response to antigen, thus provoking increased wheezing. To evaluate this possibility, 8 patients with allergic rhinitis were experimentally inoculated with rhinovirus (RV) 16. The airway response to antigen was evaluated by segmental bronchoprovocation with antigen. During the RV infection, and at recovery 4 weeks later, there was enhanced histamine release and recruitment of cells, particularly eosinophils, to the airway with antigen challenge. These findings suggest that RV infection can enhance the airway inflammatory re-sponse to antigen.

Original languageEnglish (US)
Pages (from-to)422-424
Number of pages3
JournalInternational Archives of Allergy and Immunology
Volume99
Issue number2-4
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • Asthma
  • Rhinovirus
  • Virus-induced asthma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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