Effect of Antilymphocyte Serum on Influenza Virus Infection in Mice

Fujio Suzuki, Junichi Ohya, Nakao Ishida

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Repeated injections of rabbit antiserum against mouse thymocytes (ALS) were found to increase the survival rates of mice infected with low doses of influenza A2 virus. Purified immunoglobulin of such rabbit antiserum (ALG) produced the same survival effect without affecting virus growth in lung or serum antibody responses. Lung consolidations of virus infected mice were clearly reduced by ALG administration. The study supports the concept that the cellular inflammatory reaction to influenza virus in mice plays a potentiating part in the development of morbidity and mortality after intranasal virus inoculation.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number1
DOIs
StatePublished - May 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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