Effect of antilymphocyte serum on influenza virus infection in mice

Fujio Suzuki, J. Ohya, N. Ishida

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Repeated injections of rabbit antiserum against mouse thymocytes (ALS) were found to increase the survival rates of mice infected with lose doses of influenza A2 virus. Purified immunoglobulin of such rabbit antiserum (ALG) produced the same survival effect without affecting virus growth in lung or serum antibody responses. Lung consolidations of virus infected mice were clearly reduced by ALG administration. The study supports the concept that the cellular inflammatory reaction to influenza virus in mice plays a potentiating part in the development of morbidity and mortality after intranasal virus inoculation.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume146
Issue number1
StatePublished - 1974
Externally publishedYes

Fingerprint

Antilymphocyte Serum
Virus Diseases
Orthomyxoviridae
Viruses
Immune Sera
Rabbits
Lung
Thymocytes
varespladib methyl
Antibody Formation
Immunoglobulins
Survival Rate
Consolidation
Morbidity
Injections
Mortality
Growth
Serum
Antibodies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Effect of antilymphocyte serum on influenza virus infection in mice. / Suzuki, Fujio; Ohya, J.; Ishida, N.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 146, No. 1, 1974, p. 78-84.

Research output: Contribution to journalArticle

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