Effect of Bombesin and Gastrin-Releasing Peptide on the Release of Gastric Inhibitory Polypeptide and Insulin in Rats

George H. Greeley; Alan Spannagel; John Trowbridge; James C. Thompson

doi:10.3181/00379727-182-42377

Effect of Bombesin and Gastrin-Releasing Peptide on the Release of Gastric Inhibitory Polypeptide and Insulin in Rats

George H. Greeley, Alan Spannagel, John Trowbridge, James C. Thompson

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The objective of this study was to determine whether bombesin- or gastrin-releasing peptide-induced release of insulin occurs before or after the release of gastric inhibitory polypeptide (GIP) in rats. The present results demonstrate that GIP release occurs before insulin release and suggest that bombesin-like peptides and GIP interact to stimulate insulin secretion.

Original language	English (US)
Pages (from-to)	540-542
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	182
Issue number	4
DOIs	https://doi.org/10.3181/00379727-182-42377
State	Published - Sep 1986
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3181/00379727-182-42377

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title = "Effect of Bombesin and Gastrin-Releasing Peptide on the Release of Gastric Inhibitory Polypeptide and Insulin in Rats",

abstract = "The objective of this study was to determine whether bombesin- or gastrin-releasing peptide-induced release of insulin occurs before or after the release of gastric inhibitory polypeptide (GIP) in rats. The present results demonstrate that GIP release occurs before insulin release and suggest that bombesin-like peptides and GIP interact to stimulate insulin secretion.",

author = "Greeley, {George H.} and Alan Spannagel and John Trowbridge and Thompson, {James C.}",

note = "Funding Information: Supported by grants from the National Institutes of Health (AM 15241 and AM 33021).",

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AU - Greeley, George H.

AU - Spannagel, Alan

AU - Trowbridge, John

AU - Thompson, James C.

N1 - Funding Information: Supported by grants from the National Institutes of Health (AM 15241 and AM 33021).

PY - 1986/9

Y1 - 1986/9

N2 - The objective of this study was to determine whether bombesin- or gastrin-releasing peptide-induced release of insulin occurs before or after the release of gastric inhibitory polypeptide (GIP) in rats. The present results demonstrate that GIP release occurs before insulin release and suggest that bombesin-like peptides and GIP interact to stimulate insulin secretion.

AB - The objective of this study was to determine whether bombesin- or gastrin-releasing peptide-induced release of insulin occurs before or after the release of gastric inhibitory polypeptide (GIP) in rats. The present results demonstrate that GIP release occurs before insulin release and suggest that bombesin-like peptides and GIP interact to stimulate insulin secretion.

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Effect of Bombesin and Gastrin-Releasing Peptide on the Release of Gastric Inhibitory Polypeptide and Insulin in Rats

Abstract

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