Effect of bromide on evoked release of monoamines from brain slices and intact atria

James S. Goodwin, Richard I. Katz, Irwin J. Kopin

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Many "psychoactive" drugs seem to influence monoamine metabolism in experimental animals. Such drugs have been suggested to act through their effects on monoamines in the central nervous system1. Bromide is a well known sedative although its mode of action remains uncertain. It has been suggested that the bromide ion interferes with synaptic transmission at cholinergic terminals2, but this has been disputed3. We have investigated the effect of bromide ions on release of other putative neurotransmitters - noradrenaline, serotonin and γ-aminobutyric acid.

Original languageEnglish (US)
Pages (from-to)556-557
Number of pages2
JournalNature
Volume221
Issue number5180
DOIs
StatePublished - Dec 1 1969
Externally publishedYes

ASJC Scopus subject areas

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