Effect of brussels sprouts and cabbage on drug conjugation

Eugene J. Pantuck, Carol B. Pantuck, Karl Anderson, Lee W. Wattenberg, Allan H. Conney, Attallah Kappas

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Abstract

Ten healthy subjects were fed three diets for 10 days each: a control diet, a cabbage and brussels sprouts-containing diet, and the control diet a second time. Oxazepam was taken on day 7 and acetaminophen on day 10 of each dietary regimen. The test diet stimulated the metabolism of acetaminophen, at least in part by enhanced glucuronidation, as evidenced by a 16% decrease in mean plasma AUC, a 17% increase in mean metabolic clearance rate, an increased ratio of acetaminophen glucuronide to acetaminophen in plasma from 1 to 11 hr after drug and an 8% increase in mean 24-hr urinary recovery of acetaminophen glucuronide, which returned toward control when the subjects were fed the control diet a second time. There were no comparable changes in the metabolism of acetaminophen to acetaminophen sulfate. When the subjects ate the test diet, 24-hr urinary recovery of the cysteine conjugate and of 3-methoxyacetaminophen sulfate, end-products of minor oxidative pathways, the former involving a toxic intermediate, decreased 13% and 22%. Cabbage and brussels sprouts induced a 17% decrease in mean plasma AUC and a 19% increase in mean metabolic clearance rate for oxazepam, but there was no change in mean plasma t 1 2 for this drug, nor was there a change in ratio in plasma of oxazepam glucuronide to oxazepam.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume35
Issue number2
StatePublished - Feb 1984
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Pantuck, E. J., Pantuck, C. B., Anderson, K., Wattenberg, L. W., Conney, A. H., & Kappas, A. (1984). Effect of brussels sprouts and cabbage on drug conjugation. Clinical Pharmacology and Therapeutics, 35(2), 161-169.