Effect of charcoal-broiled beef on antipyrine and theophylline metabolism

Attallah Kappas, Alvito P. Alvares, Karl Anderson, Eugene J. Pantuck, Carol B. Pantuck, R. Chang, A. H. Conney

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Eight healthy volunteers were sequentially fed a control diet, a charcoal-broiled beef-containing diet, and the control diet a second time. The mean plasma half-lives (t 1 2) of antipyrine and theophylline were each decreased by 22 % after the subjects were fed the charcoal-broiled beef-containing diet. The mean plasma t 1 2s for these drugs returned to control values when the subjects were fed the control diet for a second time. Considerable individuality occurred in the responsiveness of the subjects to the charcoal-broiled beef-containing diet. The decreases in antipyrine plasma t 1 2s among the 8 subjects ranged from 5% to 39%, and the decreases in theophylline t 1 2s ranged from 0% to 42%.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume23
Issue number4
StatePublished - Apr 1978
Externally publishedYes

Fingerprint

Antipyrine
Charcoal
Theophylline
Diet
Individuality
Red Meat
Healthy Volunteers
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kappas, A., Alvares, A. P., Anderson, K., Pantuck, E. J., Pantuck, C. B., Chang, R., & Conney, A. H. (1978). Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clinical Pharmacology and Therapeutics, 23(4), 445-450.

Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. / Kappas, Attallah; Alvares, Alvito P.; Anderson, Karl; Pantuck, Eugene J.; Pantuck, Carol B.; Chang, R.; Conney, A. H.

In: Clinical Pharmacology and Therapeutics, Vol. 23, No. 4, 04.1978, p. 445-450.

Research output: Contribution to journalArticle

Kappas, A, Alvares, AP, Anderson, K, Pantuck, EJ, Pantuck, CB, Chang, R & Conney, AH 1978, 'Effect of charcoal-broiled beef on antipyrine and theophylline metabolism', Clinical Pharmacology and Therapeutics, vol. 23, no. 4, pp. 445-450.
Kappas A, Alvares AP, Anderson K, Pantuck EJ, Pantuck CB, Chang R et al. Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. Clinical Pharmacology and Therapeutics. 1978 Apr;23(4):445-450.
Kappas, Attallah ; Alvares, Alvito P. ; Anderson, Karl ; Pantuck, Eugene J. ; Pantuck, Carol B. ; Chang, R. ; Conney, A. H. / Effect of charcoal-broiled beef on antipyrine and theophylline metabolism. In: Clinical Pharmacology and Therapeutics. 1978 ; Vol. 23, No. 4. pp. 445-450.
@article{f822eaa190594abc9c5bb7be60a6544b,
title = "Effect of charcoal-broiled beef on antipyrine and theophylline metabolism",
abstract = "Eight healthy volunteers were sequentially fed a control diet, a charcoal-broiled beef-containing diet, and the control diet a second time. The mean plasma half-lives (t 1 2) of antipyrine and theophylline were each decreased by 22 {\%} after the subjects were fed the charcoal-broiled beef-containing diet. The mean plasma t 1 2s for these drugs returned to control values when the subjects were fed the control diet for a second time. Considerable individuality occurred in the responsiveness of the subjects to the charcoal-broiled beef-containing diet. The decreases in antipyrine plasma t 1 2s among the 8 subjects ranged from 5{\%} to 39{\%}, and the decreases in theophylline t 1 2s ranged from 0{\%} to 42{\%}.",
author = "Attallah Kappas and Alvares, {Alvito P.} and Karl Anderson and Pantuck, {Eugene J.} and Pantuck, {Carol B.} and R. Chang and Conney, {A. H.}",
year = "1978",
month = "4",
language = "English (US)",
volume = "23",
pages = "445--450",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Effect of charcoal-broiled beef on antipyrine and theophylline metabolism

AU - Kappas, Attallah

AU - Alvares, Alvito P.

AU - Anderson, Karl

AU - Pantuck, Eugene J.

AU - Pantuck, Carol B.

AU - Chang, R.

AU - Conney, A. H.

PY - 1978/4

Y1 - 1978/4

N2 - Eight healthy volunteers were sequentially fed a control diet, a charcoal-broiled beef-containing diet, and the control diet a second time. The mean plasma half-lives (t 1 2) of antipyrine and theophylline were each decreased by 22 % after the subjects were fed the charcoal-broiled beef-containing diet. The mean plasma t 1 2s for these drugs returned to control values when the subjects were fed the control diet for a second time. Considerable individuality occurred in the responsiveness of the subjects to the charcoal-broiled beef-containing diet. The decreases in antipyrine plasma t 1 2s among the 8 subjects ranged from 5% to 39%, and the decreases in theophylline t 1 2s ranged from 0% to 42%.

AB - Eight healthy volunteers were sequentially fed a control diet, a charcoal-broiled beef-containing diet, and the control diet a second time. The mean plasma half-lives (t 1 2) of antipyrine and theophylline were each decreased by 22 % after the subjects were fed the charcoal-broiled beef-containing diet. The mean plasma t 1 2s for these drugs returned to control values when the subjects were fed the control diet for a second time. Considerable individuality occurred in the responsiveness of the subjects to the charcoal-broiled beef-containing diet. The decreases in antipyrine plasma t 1 2s among the 8 subjects ranged from 5% to 39%, and the decreases in theophylline t 1 2s ranged from 0% to 42%.

UR - http://www.scopus.com/inward/record.url?scp=0017836952&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017836952&partnerID=8YFLogxK

M3 - Article

C2 - 630792

AN - SCOPUS:0017836952

VL - 23

SP - 445

EP - 450

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 4

ER -